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Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients
BACKGROUND AND PURPOSE: No previous study has assessed the frequency and clinical–radiological characteristics of patients with diabetes mellitus (DM) and acute onset nonchoreic and nonballistic movements. We conducted a prospective study to investigate the spectrum of acute onset movement disorders...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542887/ https://www.ncbi.nlm.nih.gov/pubmed/35403331 http://dx.doi.org/10.1111/ene.15353 |
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author | Dubey, Souvik Chatterjee, Subhankar Ghosh, Ritwik Louis, Elan D. Hazra, Avijit Sengupta, Samya Das, Shambaditya Banerjee, Abhirup Pandit, Alak Ray, Biman Kanti Benito‐León, Julián |
author_facet | Dubey, Souvik Chatterjee, Subhankar Ghosh, Ritwik Louis, Elan D. Hazra, Avijit Sengupta, Samya Das, Shambaditya Banerjee, Abhirup Pandit, Alak Ray, Biman Kanti Benito‐León, Julián |
author_sort | Dubey, Souvik |
collection | PubMed |
description | BACKGROUND AND PURPOSE: No previous study has assessed the frequency and clinical–radiological characteristics of patients with diabetes mellitus (DM) and acute onset nonchoreic and nonballistic movements. We conducted a prospective study to investigate the spectrum of acute onset movement disorders in DM. METHODS: We recruited all the patients with acute onset movement disorders and hyperglycemia who attended the wards of three hospitals in West Bengal, India from August 2014 to July 2021. RESULTS: Among the 59 patients (mean age = 55.4 ± 14.3 years, 52.5% men) who were included, 41 (69.5%) had choreic or ballistic movements, and 18 (30.5%) had nonchoreic and nonballistic movements. Ballism was the most common movement disorder (n = 18, 30.5%), followed by pure chorea (n = 15, 25.4%), choreoathetosis (n = 8, 13.6%), tremor (n = 5, 8.5%), hemifacial spasm (n = 3, 5.1%), parkinsonism (n = 3, 5.1%), myoclonus (n = 3, 5.1%), dystonia (n = 2, 3.4%), and restless leg syndrome (n = 2, 3.4%). The mean duration of DM was 9.8 ± 11.4 years (89.8% of the patients had type 2 DM). Nonketotic hyperglycemia was frequently (76.3%) detected. The majority (55.9%) had no magnetic resonance imaging (MRI) changes; the remaining showed striatal hyperintensity. Eight patients with MRI changes exhibited discordance with sidedness of movements. Most of the patients (76.3%) recovered completely. CONCLUSIONS: This is the largest clinical series depicting the clinical–radiological spectrum of acute onset movement disorders in DM. Of note was that almost one third of patients had nonchoreic and nonballistic movements. Our findings highlight the importance of a capillary blood glucose measurement in patients with acute or subacute onset movement disorders, irrespective of their past glycemic status. |
format | Online Article Text |
id | pubmed-9542887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95428872022-10-14 Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients Dubey, Souvik Chatterjee, Subhankar Ghosh, Ritwik Louis, Elan D. Hazra, Avijit Sengupta, Samya Das, Shambaditya Banerjee, Abhirup Pandit, Alak Ray, Biman Kanti Benito‐León, Julián Eur J Neurol Movement Disorders BACKGROUND AND PURPOSE: No previous study has assessed the frequency and clinical–radiological characteristics of patients with diabetes mellitus (DM) and acute onset nonchoreic and nonballistic movements. We conducted a prospective study to investigate the spectrum of acute onset movement disorders in DM. METHODS: We recruited all the patients with acute onset movement disorders and hyperglycemia who attended the wards of three hospitals in West Bengal, India from August 2014 to July 2021. RESULTS: Among the 59 patients (mean age = 55.4 ± 14.3 years, 52.5% men) who were included, 41 (69.5%) had choreic or ballistic movements, and 18 (30.5%) had nonchoreic and nonballistic movements. Ballism was the most common movement disorder (n = 18, 30.5%), followed by pure chorea (n = 15, 25.4%), choreoathetosis (n = 8, 13.6%), tremor (n = 5, 8.5%), hemifacial spasm (n = 3, 5.1%), parkinsonism (n = 3, 5.1%), myoclonus (n = 3, 5.1%), dystonia (n = 2, 3.4%), and restless leg syndrome (n = 2, 3.4%). The mean duration of DM was 9.8 ± 11.4 years (89.8% of the patients had type 2 DM). Nonketotic hyperglycemia was frequently (76.3%) detected. The majority (55.9%) had no magnetic resonance imaging (MRI) changes; the remaining showed striatal hyperintensity. Eight patients with MRI changes exhibited discordance with sidedness of movements. Most of the patients (76.3%) recovered completely. CONCLUSIONS: This is the largest clinical series depicting the clinical–radiological spectrum of acute onset movement disorders in DM. Of note was that almost one third of patients had nonchoreic and nonballistic movements. Our findings highlight the importance of a capillary blood glucose measurement in patients with acute or subacute onset movement disorders, irrespective of their past glycemic status. John Wiley and Sons Inc. 2022-04-28 2022-08 /pmc/articles/PMC9542887/ /pubmed/35403331 http://dx.doi.org/10.1111/ene.15353 Text en © 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Movement Disorders Dubey, Souvik Chatterjee, Subhankar Ghosh, Ritwik Louis, Elan D. Hazra, Avijit Sengupta, Samya Das, Shambaditya Banerjee, Abhirup Pandit, Alak Ray, Biman Kanti Benito‐León, Julián Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title | Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title_full | Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title_fullStr | Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title_full_unstemmed | Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title_short | Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients |
title_sort | acute onset movement disorders in diabetes mellitus: a clinical series of 59 patients |
topic | Movement Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542887/ https://www.ncbi.nlm.nih.gov/pubmed/35403331 http://dx.doi.org/10.1111/ene.15353 |
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