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Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species
The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-li...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543034/ https://www.ncbi.nlm.nih.gov/pubmed/36211509 http://dx.doi.org/10.3389/fnut.2022.1003340 |
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author | Zhang, Lei Liu, Jinting Dai, Ziyan Wang, Jia Wu, Mengyang Su, Ruicong Zhang, Di |
author_facet | Zhang, Lei Liu, Jinting Dai, Ziyan Wang, Jia Wu, Mengyang Su, Ruicong Zhang, Di |
author_sort | Zhang, Lei |
collection | PubMed |
description | The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS). |
format | Online Article Text |
id | pubmed-9543034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95430342022-10-08 Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species Zhang, Lei Liu, Jinting Dai, Ziyan Wang, Jia Wu, Mengyang Su, Ruicong Zhang, Di Front Nutr Nutrition The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS). Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9543034/ /pubmed/36211509 http://dx.doi.org/10.3389/fnut.2022.1003340 Text en Copyright © 2022 Zhang, Liu, Dai, Wang, Wu, Su and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Zhang, Lei Liu, Jinting Dai, Ziyan Wang, Jia Wu, Mengyang Su, Ruicong Zhang, Di Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title | Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title_full | Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title_fullStr | Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title_full_unstemmed | Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title_short | Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
title_sort | crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543034/ https://www.ncbi.nlm.nih.gov/pubmed/36211509 http://dx.doi.org/10.3389/fnut.2022.1003340 |
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