Fragment Screening Yields a Small‐Molecule Stabilizer of 14‐3‐3 Dimers That Modulates Client Protein Interactions

The development of protein‐protein interaction (PPI) inhibitors has been a successful strategy in drug development. However, the identification of PPI stabilizers has proven much more challenging. Here we report a fragment‐based drug screening approach using the regulatory hub‐protein 14‐3‐3 as a pl...

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Detalles Bibliográficos
Autores principales: Brink, Hendrik J., Riemens, Rick, Thee, Stephanie, Beishuizen, Berend, da Costa Pereira, Daniel, Wijtmans, Maikel, de Esch, Iwan, Smit, Martine J., de Boer, Albertus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543038/
https://www.ncbi.nlm.nih.gov/pubmed/35767695
http://dx.doi.org/10.1002/cbic.202200178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543038/
https://www.ncbi.nlm.nih.gov/pubmed/35767695
http://dx.doi.org/10.1002/cbic.202200178

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