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Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period

Maternal sepsis results in poor outcomes such as fetal or maternal death. The incidence and mortality rates of maternal sepsis vary in different places because of differences in economic development, race and medical conditions. Identifying the clinical features and determining possible mechanisms f...

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Autores principales: Zhong, Xuan, Lin, Rongfeng, Zhang, Wenni, Huang, Shan, Luo, Yiping, Wang, Ding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543042/
https://www.ncbi.nlm.nih.gov/pubmed/36221418
http://dx.doi.org/10.1097/MD.0000000000030599
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author Zhong, Xuan
Lin, Rongfeng
Zhang, Wenni
Huang, Shan
Luo, Yiping
Wang, Ding
author_facet Zhong, Xuan
Lin, Rongfeng
Zhang, Wenni
Huang, Shan
Luo, Yiping
Wang, Ding
author_sort Zhong, Xuan
collection PubMed
description Maternal sepsis results in poor outcomes such as fetal or maternal death. The incidence and mortality rates of maternal sepsis vary in different places because of differences in economic development, race and medical conditions. Identifying the clinical features and determining possible mechanisms for avoiding morbidity and preventing poor outcomes would benefit committed patients. Therefore, this was an epidemiological study at a maternity transfer center in Southeast China that aimed to identify local disease features of maternal sepsis. To investigate the incidence and risk factors associated with maternal sepsis and its progression to severe sepsis in a large population-based birth cohort. This local epidemiological study was conducted in at a tertiary care center in Guangzhou, China, from 2015 to 2019. A total of 74,969 pregnant women experiencing childbirth were included in this study; Of these, 74 patients with maternal sepsis were diagnosed according to the sepsis criterion, and 118 patients without sepsis in the same period were selected randomly as the control group to study possible reasons for postpartum sepsis. This retrospective analysis covered the entire period from the first trimester to puerperium. Clinical data were collected using the hospital’s electronic medical record system. Multivariate logistic regression was used to analyze risk factors for maternal sepsis. The incidences of maternal sepsis, the maternal mortality, and the fetal mortality were 0.099%, 0.004%, and 0.007%, respectively. Septic shock was associated with a higher severity of illness. All poor outcomes (maternal or fetal death) occurred during pregnancy. Postpartum sepsis had the longest onset period, and was associated with premature rupture of fetal membranes and preeclampsia. Sepsis is an important cause of both maternal and fetal mortality. Herein, we describe an epidemiological study that evaluated the incidence, development, and prognosis of local maternal sepsis. Furthermore, the characteristics of maternal sepsis are likely due to unknown pathological mechanisms, and patients would benefit from identifying more effective treatments for maternal sepsis.
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spelling pubmed-95430422022-10-11 Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period Zhong, Xuan Lin, Rongfeng Zhang, Wenni Huang, Shan Luo, Yiping Wang, Ding Medicine (Baltimore) 5600 Maternal sepsis results in poor outcomes such as fetal or maternal death. The incidence and mortality rates of maternal sepsis vary in different places because of differences in economic development, race and medical conditions. Identifying the clinical features and determining possible mechanisms for avoiding morbidity and preventing poor outcomes would benefit committed patients. Therefore, this was an epidemiological study at a maternity transfer center in Southeast China that aimed to identify local disease features of maternal sepsis. To investigate the incidence and risk factors associated with maternal sepsis and its progression to severe sepsis in a large population-based birth cohort. This local epidemiological study was conducted in at a tertiary care center in Guangzhou, China, from 2015 to 2019. A total of 74,969 pregnant women experiencing childbirth were included in this study; Of these, 74 patients with maternal sepsis were diagnosed according to the sepsis criterion, and 118 patients without sepsis in the same period were selected randomly as the control group to study possible reasons for postpartum sepsis. This retrospective analysis covered the entire period from the first trimester to puerperium. Clinical data were collected using the hospital’s electronic medical record system. Multivariate logistic regression was used to analyze risk factors for maternal sepsis. The incidences of maternal sepsis, the maternal mortality, and the fetal mortality were 0.099%, 0.004%, and 0.007%, respectively. Septic shock was associated with a higher severity of illness. All poor outcomes (maternal or fetal death) occurred during pregnancy. Postpartum sepsis had the longest onset period, and was associated with premature rupture of fetal membranes and preeclampsia. Sepsis is an important cause of both maternal and fetal mortality. Herein, we describe an epidemiological study that evaluated the incidence, development, and prognosis of local maternal sepsis. Furthermore, the characteristics of maternal sepsis are likely due to unknown pathological mechanisms, and patients would benefit from identifying more effective treatments for maternal sepsis. Lippincott Williams & Wilkins 2022-10-07 /pmc/articles/PMC9543042/ /pubmed/36221418 http://dx.doi.org/10.1097/MD.0000000000030599 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5600
Zhong, Xuan
Lin, Rongfeng
Zhang, Wenni
Huang, Shan
Luo, Yiping
Wang, Ding
Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title_full Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title_fullStr Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title_full_unstemmed Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title_short Epidemiology and clinical features of maternal sepsis: A retrospective study of whole pregnancy period
title_sort epidemiology and clinical features of maternal sepsis: a retrospective study of whole pregnancy period
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543042/
https://www.ncbi.nlm.nih.gov/pubmed/36221418
http://dx.doi.org/10.1097/MD.0000000000030599
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