Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

OBJECTIVE: Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are known to be involved in the generation of absence seizures (ASs), and there is evidence that cortical and thalamic HCN channel dysfunctions may have a proabsence role. Many HCN channel blockers are available, but their...

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Detalles Bibliográficos
Autores principales: Iacone, Yasmine, Morais, Tatiana P., David, François, Delicata, Francis, Sandle, Joanna, Raffai, Timea, Parri, Harri Rheinallt, Weisser, Johan Juhl, Bundgaard, Christoffer, Klewe, Ib Vestergaard, Tamás, Gábor, Thomsen, Morten Skøtt, Crunelli, Vincenzo, Lőrincz, Magor L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543052/
https://www.ncbi.nlm.nih.gov/pubmed/34018186
http://dx.doi.org/10.1111/epi.16926

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