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Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)

Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. This article...

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Autores principales: Gill, Suki, Nowak, Anna K, Bowyer, Samantha, Endersby, Raelene, Ebert, Martin A, Cook, Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543060/
https://www.ncbi.nlm.nih.gov/pubmed/35699321
http://dx.doi.org/10.1111/1754-9485.13441
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author Gill, Suki
Nowak, Anna K
Bowyer, Samantha
Endersby, Raelene
Ebert, Martin A
Cook, Alistair
author_facet Gill, Suki
Nowak, Anna K
Bowyer, Samantha
Endersby, Raelene
Ebert, Martin A
Cook, Alistair
author_sort Gill, Suki
collection PubMed
description Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. This article reviews the range of cancers known to respond to immunotherapy and publications analysing SITAR. It sets the background for work that needs to be done in future clinical trials. It also reviews the potential toxicities of immunotherapy and discusses areas where caution is required when combining treatments.
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spelling pubmed-95430602022-10-14 Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR) Gill, Suki Nowak, Anna K Bowyer, Samantha Endersby, Raelene Ebert, Martin A Cook, Alistair J Med Imaging Radiat Oncol RADIATION ONCOLOGY Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the ‘Synergy between Immunotherapy and Radiotherapy’ (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. This article reviews the range of cancers known to respond to immunotherapy and publications analysing SITAR. It sets the background for work that needs to be done in future clinical trials. It also reviews the potential toxicities of immunotherapy and discusses areas where caution is required when combining treatments. Blackwell Publishing Ltd 2022-06-14 2022-09 /pmc/articles/PMC9543060/ /pubmed/35699321 http://dx.doi.org/10.1111/1754-9485.13441 Text en © 2022 The Authors. Journal of Medical Imaging and Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle RADIATION ONCOLOGY
Gill, Suki
Nowak, Anna K
Bowyer, Samantha
Endersby, Raelene
Ebert, Martin A
Cook, Alistair
Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title_full Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title_fullStr Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title_full_unstemmed Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title_short Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR)
title_sort clinical evidence for synergy between immunotherapy and radiotherapy (sitar)
topic RADIATION ONCOLOGY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543060/
https://www.ncbi.nlm.nih.gov/pubmed/35699321
http://dx.doi.org/10.1111/1754-9485.13441
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