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Altered motivation of effortful decision‐making for self and others in subthreshold depression

BACKGROUND: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear. MET...

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Autores principales: Bi, Rong, Dong, Wanxin, Zheng, Zixin, Li, Sijin, Zhang, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543190/
https://www.ncbi.nlm.nih.gov/pubmed/35657301
http://dx.doi.org/10.1002/da.23267
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author Bi, Rong
Dong, Wanxin
Zheng, Zixin
Li, Sijin
Zhang, Dandan
author_facet Bi, Rong
Dong, Wanxin
Zheng, Zixin
Li, Sijin
Zhang, Dandan
author_sort Bi, Rong
collection PubMed
description BACKGROUND: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear. METHODS: We conducted a functional magnetic resonance imaging study and employed an adapted Effort‐Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32). This required participants to choose between a fixed low‐effort/low‐reward and a variable high‐effort/high‐reward option, and then immediately exert effort to obtain corresponding rewards for themselves or for unfamiliar people. RESULTS: Compared with the HC group, the SD group showed blunted activity in the left dorsal anterior cingulate cortex/dorsomedial prefrontal cortex, bilateral anterior insula (AI), and right putamen‐left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves. Additionally, the SD group exhibited increased willingness and greater activation in the bilateral AI when choosing to exert effort for others. Furthermore, these brain activations and functional connectivity were positively related to self‐reported motivation. CONCLUSIONS: These findings show altered motivation during effort‐based decision‐making in individuals with the mild depressive state, particularly with higher motivation for others. Thus, this suggests that motivational behaviors and prefrontal–striatal circuitry are altered in individuals with SD, which can be utilized to discover treatment targets and develop strategies to address mental illness caused by motivation disorders.
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spelling pubmed-95431902022-10-14 Altered motivation of effortful decision‐making for self and others in subthreshold depression Bi, Rong Dong, Wanxin Zheng, Zixin Li, Sijin Zhang, Dandan Depress Anxiety Research Articles BACKGROUND: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear. METHODS: We conducted a functional magnetic resonance imaging study and employed an adapted Effort‐Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32). This required participants to choose between a fixed low‐effort/low‐reward and a variable high‐effort/high‐reward option, and then immediately exert effort to obtain corresponding rewards for themselves or for unfamiliar people. RESULTS: Compared with the HC group, the SD group showed blunted activity in the left dorsal anterior cingulate cortex/dorsomedial prefrontal cortex, bilateral anterior insula (AI), and right putamen‐left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves. Additionally, the SD group exhibited increased willingness and greater activation in the bilateral AI when choosing to exert effort for others. Furthermore, these brain activations and functional connectivity were positively related to self‐reported motivation. CONCLUSIONS: These findings show altered motivation during effort‐based decision‐making in individuals with the mild depressive state, particularly with higher motivation for others. Thus, this suggests that motivational behaviors and prefrontal–striatal circuitry are altered in individuals with SD, which can be utilized to discover treatment targets and develop strategies to address mental illness caused by motivation disorders. John Wiley and Sons Inc. 2022-06-03 2022 /pmc/articles/PMC9543190/ /pubmed/35657301 http://dx.doi.org/10.1002/da.23267 Text en © 2022 The Authors. Depression and Anxiety published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Bi, Rong
Dong, Wanxin
Zheng, Zixin
Li, Sijin
Zhang, Dandan
Altered motivation of effortful decision‐making for self and others in subthreshold depression
title Altered motivation of effortful decision‐making for self and others in subthreshold depression
title_full Altered motivation of effortful decision‐making for self and others in subthreshold depression
title_fullStr Altered motivation of effortful decision‐making for self and others in subthreshold depression
title_full_unstemmed Altered motivation of effortful decision‐making for self and others in subthreshold depression
title_short Altered motivation of effortful decision‐making for self and others in subthreshold depression
title_sort altered motivation of effortful decision‐making for self and others in subthreshold depression
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543190/
https://www.ncbi.nlm.nih.gov/pubmed/35657301
http://dx.doi.org/10.1002/da.23267
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