Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer

Higher frequencies of polyfunctional PD1(+)CD8(+) T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection. This study also provided a potential combin...

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Autores principales: Liu, Yanyan, Lu, Ping, Ma, Yifei, Yin, Zhucheng, Xu, Hongli, Xiang, Lanxin, Zhang, Wangli, Li, Siwei, Liang, Xinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Notes and Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543371/
https://www.ncbi.nlm.nih.gov/pubmed/35689391
http://dx.doi.org/10.1002/eji.202149570
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author Liu, Yanyan
Lu, Ping
Ma, Yifei
Yin, Zhucheng
Xu, Hongli
Xiang, Lanxin
Zhang, Wangli
Li, Siwei
Liang, Xinjun
author_facet Liu, Yanyan
Lu, Ping
Ma, Yifei
Yin, Zhucheng
Xu, Hongli
Xiang, Lanxin
Zhang, Wangli
Li, Siwei
Liang, Xinjun
author_sort Liu, Yanyan
collection PubMed
description Higher frequencies of polyfunctional PD1(+)CD8(+) T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection. This study also provided a potential combined treatment strategy with anti‐PD1 and CAR‐T therapy. [Image: see text]
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spelling pubmed-95433712022-10-14 Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer Liu, Yanyan Lu, Ping Ma, Yifei Yin, Zhucheng Xu, Hongli Xiang, Lanxin Zhang, Wangli Li, Siwei Liang, Xinjun Eur J Immunol Notes and Insights Higher frequencies of polyfunctional PD1(+)CD8(+) T cells exhibited a stronger capacity to kill tumor cells in vitro and in vivo experiments. These results suggested that peripheral polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection. This study also provided a potential combined treatment strategy with anti‐PD1 and CAR‐T therapy. [Image: see text] John Wiley and Sons Inc. 2022-06-22 2022-08 /pmc/articles/PMC9543371/ /pubmed/35689391 http://dx.doi.org/10.1002/eji.202149570 Text en © 2022 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Notes and Insights
Liu, Yanyan
Lu, Ping
Ma, Yifei
Yin, Zhucheng
Xu, Hongli
Xiang, Lanxin
Zhang, Wangli
Li, Siwei
Liang, Xinjun
Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title_full Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title_fullStr Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title_full_unstemmed Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title_short Peripheral Polyfunctional PD1(+)CD8(+) T cells demonstrated strong immune protection in non‐small cell lung cancer
title_sort peripheral polyfunctional pd1(+)cd8(+) t cells demonstrated strong immune protection in non‐small cell lung cancer
topic Notes and Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543371/
https://www.ncbi.nlm.nih.gov/pubmed/35689391
http://dx.doi.org/10.1002/eji.202149570
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