Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity

ABSTRACT: Visceral pain is a leading cause of morbidity in gastrointestinal diseases, which is exacerbated by the gut‐related side‐effects of many analgesics. New treatments are needed and further understanding of the mediators and mechanisms underpinning visceral nociception in disease states is re...

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Detalles Bibliográficos
Autores principales: Barker, Katie H., Higham, James P., Pattison, Luke A., Taylor, Toni S., Chessell, Iain P., Welsh, Fraser, Smith, Ewan St. J., Bulmer, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543404/
https://www.ncbi.nlm.nih.gov/pubmed/35775903
http://dx.doi.org/10.1113/JP283170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543404/
https://www.ncbi.nlm.nih.gov/pubmed/35775903
http://dx.doi.org/10.1113/JP283170

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