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The anti‐inflammatory peptide Catestatin blocks chemotaxis

Increased levels of the anti‐inflammatory peptide Catestatin (CST), a cleavage product of the pro‐hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (Mϕs) in inflamed...

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Detalles Bibliográficos
Autores principales: Muntjewerff, Elke M., Parv, Kristel, Mahata, Sushil K., van Riessen, N. Koen, Phillipson, Mia, Christoffersson, Gustaf, van den Bogaart, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543570/
https://www.ncbi.nlm.nih.gov/pubmed/34939227
http://dx.doi.org/10.1002/JLB.3CRA1220-790RR
Descripción
Sumario:Increased levels of the anti‐inflammatory peptide Catestatin (CST), a cleavage product of the pro‐hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (Mϕs) in inflamed tissues. Here, it is reported that CST blocks leukocyte migration toward inflammatory chemokines. By in vitro and in vivo migration assays, it is shown that although CST itself is chemotactic, it blocks migration of monocytes and neutrophils to inflammatory attracting factor CC‐chemokine ligand 2 (CCL2) and C‐X‐C motif chemokine ligand 2 (CXCL2). Moreover, it directs CX(3)CR1(+) Mϕs away from pancreatic islets. These findings suggest that the anti‐inflammatory actions of CST are partly caused by its regulation of chemotaxis.