The pleiotropic effects of α‐thalassemia on HbSS and HbSC sickle cell disease: Reduced erythrocyte cation co‐transport activity, serum erythropoietin, and transfusion burden, do not translate into increased survival

α‐Thalassemia is one of the most important genetic modulators of sickle cell disease (SCD). Both beneficial and detrimental effects have been described previously. We use a 12‐year data set on a large cohort of patients with HbSS (n = 411) and HbSC (n = 146) to examine a wide range of these clinical...

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Autores principales: Brewin, John N., Nardo‐Marino, Amina, Stuart‐Smith, Sara, El Hoss, Sara, Hanneman, Anke, Strouboulis, John, Menzel, Stephan, Gibson, John S., Rees, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543574/
https://www.ncbi.nlm.nih.gov/pubmed/35802781
http://dx.doi.org/10.1002/ajh.26652

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