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Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity

AIM: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships i...

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Autores principales: Gil‐Cosano, José J., Gracia‐Marco, Luis, Ubago‐Guisado, Esther, Migueles, Jairo H., Courteix, Daniel, Labayen, Idoia, Plaza‐Florido, Abel, Molina‐García, Pablo, Dutheil, Frédéric, Ortega, Francisco B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543891/
https://www.ncbi.nlm.nih.gov/pubmed/35708516
http://dx.doi.org/10.1111/apa.16456
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author Gil‐Cosano, José J.
Gracia‐Marco, Luis
Ubago‐Guisado, Esther
Migueles, Jairo H.
Courteix, Daniel
Labayen, Idoia
Plaza‐Florido, Abel
Molina‐García, Pablo
Dutheil, Frédéric
Ortega, Francisco B.
author_facet Gil‐Cosano, José J.
Gracia‐Marco, Luis
Ubago‐Guisado, Esther
Migueles, Jairo H.
Courteix, Daniel
Labayen, Idoia
Plaza‐Florido, Abel
Molina‐García, Pablo
Dutheil, Frédéric
Ortega, Francisco B.
author_sort Gil‐Cosano, José J.
collection PubMed
description AIM: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. METHODS: This cross‐sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual‐energy X‐ray absorptiometry was used to measure bone parameters. RESULTS: We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content. CONCLUSION: Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association.
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spelling pubmed-95438912022-10-14 Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity Gil‐Cosano, José J. Gracia‐Marco, Luis Ubago‐Guisado, Esther Migueles, Jairo H. Courteix, Daniel Labayen, Idoia Plaza‐Florido, Abel Molina‐García, Pablo Dutheil, Frédéric Ortega, Francisco B. Acta Paediatr Original Articles & Brief Reports AIM: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. METHODS: This cross‐sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual‐energy X‐ray absorptiometry was used to measure bone parameters. RESULTS: We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content. CONCLUSION: Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association. John Wiley and Sons Inc. 2022-07-05 2022-10 /pmc/articles/PMC9543891/ /pubmed/35708516 http://dx.doi.org/10.1111/apa.16456 Text en © 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles & Brief Reports
Gil‐Cosano, José J.
Gracia‐Marco, Luis
Ubago‐Guisado, Esther
Migueles, Jairo H.
Courteix, Daniel
Labayen, Idoia
Plaza‐Florido, Abel
Molina‐García, Pablo
Dutheil, Frédéric
Ortega, Francisco B.
Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title_full Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title_fullStr Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title_full_unstemmed Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title_short Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
title_sort leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
topic Original Articles & Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543891/
https://www.ncbi.nlm.nih.gov/pubmed/35708516
http://dx.doi.org/10.1111/apa.16456
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