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The potential of DNA methylation as a biomarker for obesity and smoking
DNA methylation is an epigenetic modification that has consistently been shown to be linked with a variety of human traits and diseases. Because DNA methylation is dynamic and potentially reversible in nature and can reflect environmental exposures and predict the onset of diseases, it has piqued in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543926/ https://www.ncbi.nlm.nih.gov/pubmed/35404524 http://dx.doi.org/10.1111/joim.13496 |
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author | Heikkinen, Aino Bollepalli, Sailalitha Ollikainen, Miina |
author_facet | Heikkinen, Aino Bollepalli, Sailalitha Ollikainen, Miina |
author_sort | Heikkinen, Aino |
collection | PubMed |
description | DNA methylation is an epigenetic modification that has consistently been shown to be linked with a variety of human traits and diseases. Because DNA methylation is dynamic and potentially reversible in nature and can reflect environmental exposures and predict the onset of diseases, it has piqued interest as a potential disease biomarker. DNA methylation patterns are more stable than transcriptomic or proteomic patterns, and they are relatively easy to measure to track exposure to different environments and risk factors. Importantly, technologies for DNA methylation quantification have become increasingly cost effective—accelerating new research in the field—and have enabled the development of novel DNA methylation biomarkers. Quite a few DNA methylation‐based predictors for a number of traits and diseases already exist. Such predictors show potential for being more accurate than self‐reported or measured phenotypes (such as smoking behavior and body mass index) and may even hold potential for applications in clinics. In this review, we will first discuss the advantages and challenges of DNA methylation biomarkers in general. We will then review the current state and future potential of DNA methylation biomarkers in two human traits that show rather consistent alterations in methylome—obesity and smoking. Lastly, we will briefly speculate about the future prospects of DNA methylation biomarkers, and possible ways to achieve them. |
format | Online Article Text |
id | pubmed-9543926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95439262022-10-14 The potential of DNA methylation as a biomarker for obesity and smoking Heikkinen, Aino Bollepalli, Sailalitha Ollikainen, Miina J Intern Med Reviews DNA methylation is an epigenetic modification that has consistently been shown to be linked with a variety of human traits and diseases. Because DNA methylation is dynamic and potentially reversible in nature and can reflect environmental exposures and predict the onset of diseases, it has piqued interest as a potential disease biomarker. DNA methylation patterns are more stable than transcriptomic or proteomic patterns, and they are relatively easy to measure to track exposure to different environments and risk factors. Importantly, technologies for DNA methylation quantification have become increasingly cost effective—accelerating new research in the field—and have enabled the development of novel DNA methylation biomarkers. Quite a few DNA methylation‐based predictors for a number of traits and diseases already exist. Such predictors show potential for being more accurate than self‐reported or measured phenotypes (such as smoking behavior and body mass index) and may even hold potential for applications in clinics. In this review, we will first discuss the advantages and challenges of DNA methylation biomarkers in general. We will then review the current state and future potential of DNA methylation biomarkers in two human traits that show rather consistent alterations in methylome—obesity and smoking. Lastly, we will briefly speculate about the future prospects of DNA methylation biomarkers, and possible ways to achieve them. John Wiley and Sons Inc. 2022-04-19 2022-09 /pmc/articles/PMC9543926/ /pubmed/35404524 http://dx.doi.org/10.1111/joim.13496 Text en © 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Heikkinen, Aino Bollepalli, Sailalitha Ollikainen, Miina The potential of DNA methylation as a biomarker for obesity and smoking |
title | The potential of DNA methylation as a biomarker for obesity and smoking |
title_full | The potential of DNA methylation as a biomarker for obesity and smoking |
title_fullStr | The potential of DNA methylation as a biomarker for obesity and smoking |
title_full_unstemmed | The potential of DNA methylation as a biomarker for obesity and smoking |
title_short | The potential of DNA methylation as a biomarker for obesity and smoking |
title_sort | potential of dna methylation as a biomarker for obesity and smoking |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9543926/ https://www.ncbi.nlm.nih.gov/pubmed/35404524 http://dx.doi.org/10.1111/joim.13496 |
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