Cargando…

Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis

This rapid review summarizes the most up to date evidence about the risk factors for severe food‐induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertak...

Descripción completa

Detalles Bibliográficos
Autores principales: Turner, Paul J., Arasi, Stefania, Ballmer‐Weber, Barbara, Baseggio Conrado, Alessia, Deschildre, Antoine, Gerdts, Jennifer, Halken, Susanne, Muraro, Antonella, Patel, Nandinee, Van Ree, Ronald, de Silva, Debra, Worm, Margitta, Zuberbier, Torsten, Roberts, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544052/
https://www.ncbi.nlm.nih.gov/pubmed/35441718
http://dx.doi.org/10.1111/all.15318
_version_ 1784804514073673728
author Turner, Paul J.
Arasi, Stefania
Ballmer‐Weber, Barbara
Baseggio Conrado, Alessia
Deschildre, Antoine
Gerdts, Jennifer
Halken, Susanne
Muraro, Antonella
Patel, Nandinee
Van Ree, Ronald
de Silva, Debra
Worm, Margitta
Zuberbier, Torsten
Roberts, Graham
author_facet Turner, Paul J.
Arasi, Stefania
Ballmer‐Weber, Barbara
Baseggio Conrado, Alessia
Deschildre, Antoine
Gerdts, Jennifer
Halken, Susanne
Muraro, Antonella
Patel, Nandinee
Van Ree, Ronald
de Silva, Debra
Worm, Margitta
Zuberbier, Torsten
Roberts, Graham
author_sort Turner, Paul J.
collection PubMed
description This rapid review summarizes the most up to date evidence about the risk factors for severe food‐induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta‐analysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Prior anaphylaxis, an asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors. Some molecular allergology markers may be helpful. Hospital presentations for anaphylaxis are highest in young children, yet this age group appears at lower risk of severe outcomes. Risk of severe outcomes is greatest in adolescence and young adulthood, but the contribution of risk taking behaviour in contributing to severe outcomes is unclear. Evidence for an impact of cofactors on severity is lacking, although food‐dependent exercise‐induced anaphylaxis may be an exception. Some medications such as beta‐blockers or ACE inhibitors may increase severity, but appear less important than age as a factor in life‐threatening reactions. The relationship between dose of exposure and severity is unclear. Delays in symptom recognition and anaphylaxis treatment have been associated with more severe outcomes. An absence of prior anaphylaxis does not exclude its future risk.
format Online
Article
Text
id pubmed-9544052
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-95440522022-10-14 Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis Turner, Paul J. Arasi, Stefania Ballmer‐Weber, Barbara Baseggio Conrado, Alessia Deschildre, Antoine Gerdts, Jennifer Halken, Susanne Muraro, Antonella Patel, Nandinee Van Ree, Ronald de Silva, Debra Worm, Margitta Zuberbier, Torsten Roberts, Graham Allergy Review Articles This rapid review summarizes the most up to date evidence about the risk factors for severe food‐induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta‐analysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Prior anaphylaxis, an asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors. Some molecular allergology markers may be helpful. Hospital presentations for anaphylaxis are highest in young children, yet this age group appears at lower risk of severe outcomes. Risk of severe outcomes is greatest in adolescence and young adulthood, but the contribution of risk taking behaviour in contributing to severe outcomes is unclear. Evidence for an impact of cofactors on severity is lacking, although food‐dependent exercise‐induced anaphylaxis may be an exception. Some medications such as beta‐blockers or ACE inhibitors may increase severity, but appear less important than age as a factor in life‐threatening reactions. The relationship between dose of exposure and severity is unclear. Delays in symptom recognition and anaphylaxis treatment have been associated with more severe outcomes. An absence of prior anaphylaxis does not exclude its future risk. John Wiley and Sons Inc. 2022-04-28 2022-09 /pmc/articles/PMC9544052/ /pubmed/35441718 http://dx.doi.org/10.1111/all.15318 Text en © 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Turner, Paul J.
Arasi, Stefania
Ballmer‐Weber, Barbara
Baseggio Conrado, Alessia
Deschildre, Antoine
Gerdts, Jennifer
Halken, Susanne
Muraro, Antonella
Patel, Nandinee
Van Ree, Ronald
de Silva, Debra
Worm, Margitta
Zuberbier, Torsten
Roberts, Graham
Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title_full Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title_fullStr Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title_full_unstemmed Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title_short Risk factors for severe reactions in food allergy: Rapid evidence review with meta‐analysis
title_sort risk factors for severe reactions in food allergy: rapid evidence review with meta‐analysis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544052/
https://www.ncbi.nlm.nih.gov/pubmed/35441718
http://dx.doi.org/10.1111/all.15318
work_keys_str_mv AT turnerpaulj riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT arasistefania riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT ballmerweberbarbara riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT baseggioconradoalessia riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT deschildreantoine riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT gerdtsjennifer riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT halkensusanne riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT muraroantonella riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT patelnandinee riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT vanreeronald riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT desilvadebra riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT wormmargitta riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT zuberbiertorsten riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT robertsgraham riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis
AT riskfactorsforseverereactionsinfoodallergyrapidevidencereviewwithmetaanalysis