BioWF: A Naturally‐Fused, Di‐Domain Biocatalyst from Biotin Biosynthesis Displays an Unexpectedly Broad Substrate Scope

The carbon backbone of biotin is constructed from the C(7) di‐acid pimelate, which is converted to an acyl‐CoA thioester by an ATP‐dependent, pimeloyl‐CoA synthetase (PCAS, encoded by BioW). The acyl‐thioester is condensed with ʟ‐alanine in a decarboxylative, Claisen‐like reaction to form an aminoke...

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Detalles Bibliográficos
Autores principales: Richardson, Shona M., Harrison, Peter J., Herrera, Michael A., Wang, Menglu, Verez, Rebecca, Ortiz, Gustavo Perez, Campopiano, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544090/
https://www.ncbi.nlm.nih.gov/pubmed/35695820
http://dx.doi.org/10.1002/cbic.202200171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544090/
https://www.ncbi.nlm.nih.gov/pubmed/35695820
http://dx.doi.org/10.1002/cbic.202200171

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