Suppression of Liquid‐Liquid Phase Separation and Aggregation of Antibodies by Modest Pressure Application

The high colloidal stability of antibody (immunoglobulin) solutions is important for pharmaceutical applications. Inert cosolutes, excipients, are generally used in therapeutic protein formulations to minimize physical instabilities, such as liquid–liquid phase separation (LLPS), aggregation and pre...

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Detalles Bibliográficos
Autores principales: Fetahaj, Zamira, Jaworek, Michel W., Oliva, Rosario, Winter, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544093/
https://www.ncbi.nlm.nih.gov/pubmed/35759377
http://dx.doi.org/10.1002/chem.202201658

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