Cargando…
Bayesian adaptive clinical trial designs for respiratory medicine
The use of Bayesian adaptive designs for clinical trials has increased in recent years, particularly during the COVID‐19 pandemic. Bayesian adaptive designs offer a flexible and efficient framework for conducting clinical trials and may provide results that are more useful and natural to interpret f...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544135/ https://www.ncbi.nlm.nih.gov/pubmed/35918280 http://dx.doi.org/10.1111/resp.14337 |
_version_ | 1784804532724695040 |
---|---|
author | Ryan, Elizabeth G. Couturier, Dominique‐Laurent Heritier, Stephane |
author_facet | Ryan, Elizabeth G. Couturier, Dominique‐Laurent Heritier, Stephane |
author_sort | Ryan, Elizabeth G. |
collection | PubMed |
description | The use of Bayesian adaptive designs for clinical trials has increased in recent years, particularly during the COVID‐19 pandemic. Bayesian adaptive designs offer a flexible and efficient framework for conducting clinical trials and may provide results that are more useful and natural to interpret for clinicians, compared to traditional approaches. In this review, we provide an introduction to Bayesian adaptive designs and discuss its use in recent clinical trials conducted in respiratory medicine. We illustrate this approach by constructing a Bayesian adaptive design for a multi‐arm trial that compares two non‐invasive ventilation treatments to standard oxygen therapy for patients with acute cardiogenic pulmonary oedema. We highlight the benefits and some of the challenges involved in designing and implementing Bayesian adaptive trials. |
format | Online Article Text |
id | pubmed-9544135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-95441352022-10-14 Bayesian adaptive clinical trial designs for respiratory medicine Ryan, Elizabeth G. Couturier, Dominique‐Laurent Heritier, Stephane Respirology Invited Review The use of Bayesian adaptive designs for clinical trials has increased in recent years, particularly during the COVID‐19 pandemic. Bayesian adaptive designs offer a flexible and efficient framework for conducting clinical trials and may provide results that are more useful and natural to interpret for clinicians, compared to traditional approaches. In this review, we provide an introduction to Bayesian adaptive designs and discuss its use in recent clinical trials conducted in respiratory medicine. We illustrate this approach by constructing a Bayesian adaptive design for a multi‐arm trial that compares two non‐invasive ventilation treatments to standard oxygen therapy for patients with acute cardiogenic pulmonary oedema. We highlight the benefits and some of the challenges involved in designing and implementing Bayesian adaptive trials. John Wiley & Sons, Ltd 2022-08-02 2022-10 /pmc/articles/PMC9544135/ /pubmed/35918280 http://dx.doi.org/10.1111/resp.14337 Text en © 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Ryan, Elizabeth G. Couturier, Dominique‐Laurent Heritier, Stephane Bayesian adaptive clinical trial designs for respiratory medicine |
title | Bayesian adaptive clinical trial designs for respiratory medicine |
title_full | Bayesian adaptive clinical trial designs for respiratory medicine |
title_fullStr | Bayesian adaptive clinical trial designs for respiratory medicine |
title_full_unstemmed | Bayesian adaptive clinical trial designs for respiratory medicine |
title_short | Bayesian adaptive clinical trial designs for respiratory medicine |
title_sort | bayesian adaptive clinical trial designs for respiratory medicine |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544135/ https://www.ncbi.nlm.nih.gov/pubmed/35918280 http://dx.doi.org/10.1111/resp.14337 |
work_keys_str_mv | AT ryanelizabethg bayesianadaptiveclinicaltrialdesignsforrespiratorymedicine AT couturierdominiquelaurent bayesianadaptiveclinicaltrialdesignsforrespiratorymedicine AT heritierstephane bayesianadaptiveclinicaltrialdesignsforrespiratorymedicine |