The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network

Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non‐spore‐forming Lactococcus lactis KF147 progressively activates the expression of stress‐associated functions in response to...

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Autores principales: Ercan, Onur, den Besten, Heidy M. W., Smid, Eddy J., Kleerebezem, Michiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544163/
https://www.ncbi.nlm.nih.gov/pubmed/35445553
http://dx.doi.org/10.1111/1758-2229.13073
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author Ercan, Onur
den Besten, Heidy M. W.
Smid, Eddy J.
Kleerebezem, Michiel
author_facet Ercan, Onur
den Besten, Heidy M. W.
Smid, Eddy J.
Kleerebezem, Michiel
author_sort Ercan, Onur
collection PubMed
description Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non‐spore‐forming Lactococcus lactis KF147 progressively activates the expression of stress‐associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 10(4)‐fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress‐tolerance adaptations underlying the growth‐survival trade‐off in L. lactis, and exemplify the hard‐wiring of this trade‐off in the lactococcal gene regulation network.
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spelling pubmed-95441632022-10-14 The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network Ercan, Onur den Besten, Heidy M. W. Smid, Eddy J. Kleerebezem, Michiel Environ Microbiol Rep Brief Reports Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non‐spore‐forming Lactococcus lactis KF147 progressively activates the expression of stress‐associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 10(4)‐fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress‐tolerance adaptations underlying the growth‐survival trade‐off in L. lactis, and exemplify the hard‐wiring of this trade‐off in the lactococcal gene regulation network. John Wiley & Sons, Inc. 2022-04-21 2022-08 /pmc/articles/PMC9544163/ /pubmed/35445553 http://dx.doi.org/10.1111/1758-2229.13073 Text en © 2022 The Authors. Environmental Microbiology Reports published by Society for Applied Microbiology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Reports
Ercan, Onur
den Besten, Heidy M. W.
Smid, Eddy J.
Kleerebezem, Michiel
The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title_full The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title_fullStr The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title_full_unstemmed The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title_short The growth‐survival trade‐off is hard‐wired in the Lactococcus lactis gene regulation network
title_sort growth‐survival trade‐off is hard‐wired in the lactococcus lactis gene regulation network
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544163/
https://www.ncbi.nlm.nih.gov/pubmed/35445553
http://dx.doi.org/10.1111/1758-2229.13073
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