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Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature
BACKGROUND: Sleep is essential to maintaining a healthy life. Sleep disturbances among individuals with neurodevelopmental disorders are not well studied, affecting their early detection and treatment. Sleep disturbances in individuals with Phelan–McDermid Syndrome (PMS) are among the primary concer...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544216/ https://www.ncbi.nlm.nih.gov/pubmed/35996993 http://dx.doi.org/10.1002/mgg3.2035 |
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author | Moffitt, Bridgette A. Sarasua, Sara M. Ward, Linda Ivankovic, Diana Valentine, Kathleen Rogers, Curtis Phelan, Katy Boccuto, Luigi |
author_facet | Moffitt, Bridgette A. Sarasua, Sara M. Ward, Linda Ivankovic, Diana Valentine, Kathleen Rogers, Curtis Phelan, Katy Boccuto, Luigi |
author_sort | Moffitt, Bridgette A. |
collection | PubMed |
description | BACKGROUND: Sleep is essential to maintaining a healthy life. Sleep disturbances among individuals with neurodevelopmental disorders are not well studied, affecting their early detection and treatment. Sleep disturbances in individuals with Phelan–McDermid Syndrome (PMS) are among the primary concerns reported by parents. However, little research has been aimed at addressing their concern. METHODS: The purpose of this investigation was to identify and quantify specific sleep disturbances in people with PMS by analyzing data collected by the PMS Foundation International Registry. RESULTS: The registry shows that 284 out of 384 (73.4%) individuals with confirmed chromosome 22q13 deletions or SHANK3 pathogenic variants have a sleep disturbance. The prevalence of sleep disturbances increases with age with 56% reporting a sleep disturbance in the 0–3 year age group and 90% reporting these disturbances in those over age 18 years old. The primary sleep disturbances were circadian rhythm sleep disorders that included difficulty falling asleep, frequent nighttime awakenings, difficulty returning to sleep after a nighttime awakening event, and hypersomnia and parasomnias including enuresis, night terrors, sleepwalking, and sleep apnea. Sleep disturbances were similarly frequent among individuals with SHANK3 pathogenic variants (84.8%) and those with deletions (71.9%), supporting the role of haploinsufficiency of SHANK3 in sleep. CONCLUSION: Sleep disturbances are a common feature of PMS and should be considered in clinical evaluation and management because of the effect they have on the quality of life of the patients and their families. |
format | Online Article Text |
id | pubmed-9544216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95442162022-10-14 Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature Moffitt, Bridgette A. Sarasua, Sara M. Ward, Linda Ivankovic, Diana Valentine, Kathleen Rogers, Curtis Phelan, Katy Boccuto, Luigi Mol Genet Genomic Med Original Articles BACKGROUND: Sleep is essential to maintaining a healthy life. Sleep disturbances among individuals with neurodevelopmental disorders are not well studied, affecting their early detection and treatment. Sleep disturbances in individuals with Phelan–McDermid Syndrome (PMS) are among the primary concerns reported by parents. However, little research has been aimed at addressing their concern. METHODS: The purpose of this investigation was to identify and quantify specific sleep disturbances in people with PMS by analyzing data collected by the PMS Foundation International Registry. RESULTS: The registry shows that 284 out of 384 (73.4%) individuals with confirmed chromosome 22q13 deletions or SHANK3 pathogenic variants have a sleep disturbance. The prevalence of sleep disturbances increases with age with 56% reporting a sleep disturbance in the 0–3 year age group and 90% reporting these disturbances in those over age 18 years old. The primary sleep disturbances were circadian rhythm sleep disorders that included difficulty falling asleep, frequent nighttime awakenings, difficulty returning to sleep after a nighttime awakening event, and hypersomnia and parasomnias including enuresis, night terrors, sleepwalking, and sleep apnea. Sleep disturbances were similarly frequent among individuals with SHANK3 pathogenic variants (84.8%) and those with deletions (71.9%), supporting the role of haploinsufficiency of SHANK3 in sleep. CONCLUSION: Sleep disturbances are a common feature of PMS and should be considered in clinical evaluation and management because of the effect they have on the quality of life of the patients and their families. John Wiley and Sons Inc. 2022-08-23 /pmc/articles/PMC9544216/ /pubmed/35996993 http://dx.doi.org/10.1002/mgg3.2035 Text en © 2022 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Moffitt, Bridgette A. Sarasua, Sara M. Ward, Linda Ivankovic, Diana Valentine, Kathleen Rogers, Curtis Phelan, Katy Boccuto, Luigi Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title | Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title_full | Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title_fullStr | Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title_full_unstemmed | Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title_short | Sleep and Phelan–McDermid Syndrome: Lessons from the International Registry and the scientific literature |
title_sort | sleep and phelan–mcdermid syndrome: lessons from the international registry and the scientific literature |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544216/ https://www.ncbi.nlm.nih.gov/pubmed/35996993 http://dx.doi.org/10.1002/mgg3.2035 |
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