Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression associated with cancer-driven nocifensive behaviors. T...

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Detalles Bibliográficos
Autores principales: Tang, Philip Chiu-Tsun, Chung, Jeff Yat-Fai, Liao, Jinyue, Chan, Max Kam-Kwan, Chan, Alex Siu-Wing, Cheng, Guangyao, Li, Chunjie, Huang, Xiao-Ru, Ng, Calvin Sze-Hang, Lam, Eric W-F, Zhang, Dongmei, Ho, Yi-Ping, To, Ka-Fai, Leung, Kam-Tong, Jiang, Xiaohua, Ko, Ho, Lee, Tin-Lap, Lan, Hui-Yao, Tang, Patrick Ming-Kuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544324/
https://www.ncbi.nlm.nih.gov/pubmed/36206343
http://dx.doi.org/10.1126/sciadv.abn5535

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