Oncogenic role of a developmentally regulated NTRK2 splice variant

Temporally regulated alternative splicing choices are vital for proper development, yet the wrong splice choice may be detrimental. Here, we highlight a previously unidentified role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, embryogenesis, transformation, and oncogenes...

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Detalles Bibliográficos
Autores principales: Pattwell, Siobhan S., Arora, Sonali, Nuechterlein, Nicholas, Zager, Michael, Loeb, Keith R., Cimino, Patrick J., Holland, Nikolas C., Reche-Ley, Noemi, Bolouri, Hamid, Almiron Bonnin, Damian A., Szulzewsky, Frank, Phadnis, Vaishnavi V., Ozawa, Tatsuya, Wagner, Michael J., Haffner, Michael C., Cao, Junyue, Shendure, Jay, Holland, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544329/
https://www.ncbi.nlm.nih.gov/pubmed/36206341
http://dx.doi.org/10.1126/sciadv.abo6789

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