Cargando…
Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon
A controlled Saprolegnia parasitica infection model was used to challenge 1158 fish representing 105 pedigreed Atlantic salmon families to evaluate the possibility of selecting for Saprolegnia resistance in a commercial breeding programme. Fish were infected in five study tanks and observed for 40 d...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544413/ https://www.ncbi.nlm.nih.gov/pubmed/35661373 http://dx.doi.org/10.1111/jfd.13664 |
_version_ | 1784804590779105280 |
---|---|
author | Misk, Ehab Gonen, Serap Garber, Amber F. |
author_facet | Misk, Ehab Gonen, Serap Garber, Amber F. |
author_sort | Misk, Ehab |
collection | PubMed |
description | A controlled Saprolegnia parasitica infection model was used to challenge 1158 fish representing 105 pedigreed Atlantic salmon families to evaluate the possibility of selecting for Saprolegnia resistance in a commercial breeding programme. Fish were infected in five study tanks and observed for 40 days post‐infection for lesion score and survival. Survival analysis of the top 10 resistant and bottom 10 susceptible families indicated that the hazard of dying following Saprolegnia infection was 1509% higher in susceptible families. In all fish, a 10 g increase in weight correlated with a 7.8% increase in the hazard of dying while sex did not affect mortality. Resistance to Saprolegnia was estimated to have a heritability of 0.25, indicating that selection is possible. Genetic and phenotypic correlations indicated that the 11‐point scoring system, developed in this study to quantify Saprolegnia infection severity, had a high negative correlation with survival as days to mortality at ≥−0.922(±0.005), suggesting that the scoring method could help assess lesion development in studies where mortality is not the primary biological endpoint. |
format | Online Article Text |
id | pubmed-9544413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95444132022-10-14 Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon Misk, Ehab Gonen, Serap Garber, Amber F. J Fish Dis Research Articles A controlled Saprolegnia parasitica infection model was used to challenge 1158 fish representing 105 pedigreed Atlantic salmon families to evaluate the possibility of selecting for Saprolegnia resistance in a commercial breeding programme. Fish were infected in five study tanks and observed for 40 days post‐infection for lesion score and survival. Survival analysis of the top 10 resistant and bottom 10 susceptible families indicated that the hazard of dying following Saprolegnia infection was 1509% higher in susceptible families. In all fish, a 10 g increase in weight correlated with a 7.8% increase in the hazard of dying while sex did not affect mortality. Resistance to Saprolegnia was estimated to have a heritability of 0.25, indicating that selection is possible. Genetic and phenotypic correlations indicated that the 11‐point scoring system, developed in this study to quantify Saprolegnia infection severity, had a high negative correlation with survival as days to mortality at ≥−0.922(±0.005), suggesting that the scoring method could help assess lesion development in studies where mortality is not the primary biological endpoint. John Wiley and Sons Inc. 2022-06-04 2022-09 /pmc/articles/PMC9544413/ /pubmed/35661373 http://dx.doi.org/10.1111/jfd.13664 Text en © 2022 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Misk, Ehab Gonen, Serap Garber, Amber F. Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title | Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title_full | Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title_fullStr | Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title_full_unstemmed | Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title_short | Resistance to Saprolegnia parasitica infection: A heritable trait in Atlantic salmon |
title_sort | resistance to saprolegnia parasitica infection: a heritable trait in atlantic salmon |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544413/ https://www.ncbi.nlm.nih.gov/pubmed/35661373 http://dx.doi.org/10.1111/jfd.13664 |
work_keys_str_mv | AT miskehab resistancetosaprolegniaparasiticainfectionaheritabletraitinatlanticsalmon AT gonenserap resistancetosaprolegniaparasiticainfectionaheritabletraitinatlanticsalmon AT garberamberf resistancetosaprolegniaparasiticainfectionaheritabletraitinatlanticsalmon |