Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy

The stromal niche plays a pivotal role in AML chemoresistance and energy metabolism reprogramming is a hallmark of a tumor. 5′‐Adenosine monophosphate‐activated protein kinase (AMPK) is an important energy sensor suppressing mammalian target of rapamycin complex 1 (mTORC1) activity. However, the rol...

Descripción completa

Detalles Bibliográficos
Autores principales: You, Ruolan, Hou, Diyu, Wang, Bin, Liu, Jingru, Wang, Xiaoting, Xiao, Qirong, Pan, Zhipeng, Li, Dongliang, Feng, Xiaoming, Kang, Lixia, Chen, Ping, Huang, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
System Biology and Immunogenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544716/
https://www.ncbi.nlm.nih.gov/pubmed/34927743
http://dx.doi.org/10.1002/JLB.6A0821-409RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544716/
https://www.ncbi.nlm.nih.gov/pubmed/34927743
http://dx.doi.org/10.1002/JLB.6A0821-409RR

Ejemplares similares