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Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy

The stromal niche plays a pivotal role in AML chemoresistance and energy metabolism reprogramming is a hallmark of a tumor. 5′‐Adenosine monophosphate‐activated protein kinase (AMPK) is an important energy sensor suppressing mammalian target of rapamycin complex 1 (mTORC1) activity. However, the rol...

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Detalles Bibliográficos
Autores principales:	You, Ruolan, Hou, Diyu, Wang, Bin, Liu, Jingru, Wang, Xiaoting, Xiao, Qirong, Pan, Zhipeng, Li, Dongliang, Feng, Xiaoming, Kang, Lixia, Chen, Ping, Huang, Huifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	System Biology and Immunogenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544716/ https://www.ncbi.nlm.nih.gov/pubmed/34927743 http://dx.doi.org/10.1002/JLB.6A0821-409RR

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