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Current approaches for the regeneration and reconstruction of ocular surface in dry eye

Significant research revealed the preocular tear film composition and regulations that remain vital for maintaining Ocular surface functional integrity. Inflammation triggered by many factors is the hallmark of Ocular surface disorders or dry eyes syndrome (DES). The tear deficiencies may lead to oc...

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Autores principales: Singh, Vimal Kishor, Sharma, Pallavi, Vaksh, Uttkarsh Kumar Sharma, Chandra, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544815/
https://www.ncbi.nlm.nih.gov/pubmed/36213677
http://dx.doi.org/10.3389/fmed.2022.885780
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author Singh, Vimal Kishor
Sharma, Pallavi
Vaksh, Uttkarsh Kumar Sharma
Chandra, Ramesh
author_facet Singh, Vimal Kishor
Sharma, Pallavi
Vaksh, Uttkarsh Kumar Sharma
Chandra, Ramesh
author_sort Singh, Vimal Kishor
collection PubMed
description Significant research revealed the preocular tear film composition and regulations that remain vital for maintaining Ocular surface functional integrity. Inflammation triggered by many factors is the hallmark of Ocular surface disorders or dry eyes syndrome (DES). The tear deficiencies may lead to ocular surface desiccation, corneal ulceration and/or perforation, higher rates of infectious disease, and the risk of severe visual impairment and blindness. Clinical management remains largely supportive, palliative, and frequent, lifelong use of different lubricating agents. However, few advancements such as punctal plugs, non-steroidal anti-inflammatory drugs, and salivary gland autografts are of limited use. Cell-based therapies, tissue engineering, and regenerative medicine, have recently evolved as long-term cures for many diseases, including ophthalmic diseases. The present article focuses on the different regenerative medicine and reconstruction/bioengineered lacrimal gland formation strategies reported so far, along with their limiting factors and feasibility as an effective cure in future.
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spelling pubmed-95448152022-10-08 Current approaches for the regeneration and reconstruction of ocular surface in dry eye Singh, Vimal Kishor Sharma, Pallavi Vaksh, Uttkarsh Kumar Sharma Chandra, Ramesh Front Med (Lausanne) Medicine Significant research revealed the preocular tear film composition and regulations that remain vital for maintaining Ocular surface functional integrity. Inflammation triggered by many factors is the hallmark of Ocular surface disorders or dry eyes syndrome (DES). The tear deficiencies may lead to ocular surface desiccation, corneal ulceration and/or perforation, higher rates of infectious disease, and the risk of severe visual impairment and blindness. Clinical management remains largely supportive, palliative, and frequent, lifelong use of different lubricating agents. However, few advancements such as punctal plugs, non-steroidal anti-inflammatory drugs, and salivary gland autografts are of limited use. Cell-based therapies, tissue engineering, and regenerative medicine, have recently evolved as long-term cures for many diseases, including ophthalmic diseases. The present article focuses on the different regenerative medicine and reconstruction/bioengineered lacrimal gland formation strategies reported so far, along with their limiting factors and feasibility as an effective cure in future. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9544815/ /pubmed/36213677 http://dx.doi.org/10.3389/fmed.2022.885780 Text en Copyright © 2022 Singh, Sharma, Vaksh and Chandra. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Singh, Vimal Kishor
Sharma, Pallavi
Vaksh, Uttkarsh Kumar Sharma
Chandra, Ramesh
Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title_full Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title_fullStr Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title_full_unstemmed Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title_short Current approaches for the regeneration and reconstruction of ocular surface in dry eye
title_sort current approaches for the regeneration and reconstruction of ocular surface in dry eye
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544815/
https://www.ncbi.nlm.nih.gov/pubmed/36213677
http://dx.doi.org/10.3389/fmed.2022.885780
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