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Validation of new diagnostic criteria for fatigue in patients with Parkinson disease

BACKGROUND AND PURPOSE: Although disabling fatigue is common in Parkinson disease (PD), available consensus‐based diagnostic criteria have not yet been empirically validated. The aim of this study was to evaluate the clinimetric properties of the criteria. METHODS: A sample of outpatients with PD wa...

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Autores principales: Siciliano, Mattia, Kluger, Benzi, De Micco, Rosa, Chiorri, Carlo, Sant'Elia, Valeria, Silvestro, Marcello, Giordano, Alfonso, Tedeschi, Gioacchino, Passamonti, Luca, Trojano, Luigi, Tessitore, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544823/
https://www.ncbi.nlm.nih.gov/pubmed/35587108
http://dx.doi.org/10.1111/ene.15411
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author Siciliano, Mattia
Kluger, Benzi
De Micco, Rosa
Chiorri, Carlo
Sant'Elia, Valeria
Silvestro, Marcello
Giordano, Alfonso
Tedeschi, Gioacchino
Passamonti, Luca
Trojano, Luigi
Tessitore, Alessandro
author_facet Siciliano, Mattia
Kluger, Benzi
De Micco, Rosa
Chiorri, Carlo
Sant'Elia, Valeria
Silvestro, Marcello
Giordano, Alfonso
Tedeschi, Gioacchino
Passamonti, Luca
Trojano, Luigi
Tessitore, Alessandro
author_sort Siciliano, Mattia
collection PubMed
description BACKGROUND AND PURPOSE: Although disabling fatigue is common in Parkinson disease (PD), available consensus‐based diagnostic criteria have not yet been empirically validated. The aim of this study was to evaluate the clinimetric properties of the criteria. METHODS: A sample of outpatients with PD was evaluated for demographic, clinical, behavioral, and cognitive features. Fatigue was diagnosed according to the new diagnostic criteria and was rated by means of the Parkinson Fatigue Scale (PFS) and Fatigue Severity Scale (FSS). Acceptability, concurrent and discriminant validity, and interrater reliability were evaluated with binary logistic regression analyses and Cohen kappa (κ). RESULTS: Of 241 included patients, 17 (7.1%) met the diagnostic criteria for PD‐related fatigue. Eight of nine symptoms described in Section A of the diagnostic criteria occurred in >50% of patients with fatigue. Acceptability (missing data = 0.8%) of the criteria was good, as was their concurrent validity with the PFS (odds ratio = 3.65) and FSS (odds ratio = 3.63). The discriminant validity of fatigue criteria with other PD‐related behavioral and cognitive features was good (odds ratio < 1.68). The interrater reliability was excellent (κ = 0.92). CONCLUSIONS: This is the first study to test the clinimetric properties of case definition diagnostic criteria for PD‐related fatigue. Our results suggest that current diagnostic criteria may be useful in both clinical practice and research. Future longitudinal studies should examine their long‐term stability.
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spelling pubmed-95448232022-10-14 Validation of new diagnostic criteria for fatigue in patients with Parkinson disease Siciliano, Mattia Kluger, Benzi De Micco, Rosa Chiorri, Carlo Sant'Elia, Valeria Silvestro, Marcello Giordano, Alfonso Tedeschi, Gioacchino Passamonti, Luca Trojano, Luigi Tessitore, Alessandro Eur J Neurol Movement Disorders BACKGROUND AND PURPOSE: Although disabling fatigue is common in Parkinson disease (PD), available consensus‐based diagnostic criteria have not yet been empirically validated. The aim of this study was to evaluate the clinimetric properties of the criteria. METHODS: A sample of outpatients with PD was evaluated for demographic, clinical, behavioral, and cognitive features. Fatigue was diagnosed according to the new diagnostic criteria and was rated by means of the Parkinson Fatigue Scale (PFS) and Fatigue Severity Scale (FSS). Acceptability, concurrent and discriminant validity, and interrater reliability were evaluated with binary logistic regression analyses and Cohen kappa (κ). RESULTS: Of 241 included patients, 17 (7.1%) met the diagnostic criteria for PD‐related fatigue. Eight of nine symptoms described in Section A of the diagnostic criteria occurred in >50% of patients with fatigue. Acceptability (missing data = 0.8%) of the criteria was good, as was their concurrent validity with the PFS (odds ratio = 3.65) and FSS (odds ratio = 3.63). The discriminant validity of fatigue criteria with other PD‐related behavioral and cognitive features was good (odds ratio < 1.68). The interrater reliability was excellent (κ = 0.92). CONCLUSIONS: This is the first study to test the clinimetric properties of case definition diagnostic criteria for PD‐related fatigue. Our results suggest that current diagnostic criteria may be useful in both clinical practice and research. Future longitudinal studies should examine their long‐term stability. John Wiley and Sons Inc. 2022-06-06 2022-09 /pmc/articles/PMC9544823/ /pubmed/35587108 http://dx.doi.org/10.1111/ene.15411 Text en © 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Movement Disorders
Siciliano, Mattia
Kluger, Benzi
De Micco, Rosa
Chiorri, Carlo
Sant'Elia, Valeria
Silvestro, Marcello
Giordano, Alfonso
Tedeschi, Gioacchino
Passamonti, Luca
Trojano, Luigi
Tessitore, Alessandro
Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title_full Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title_fullStr Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title_full_unstemmed Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title_short Validation of new diagnostic criteria for fatigue in patients with Parkinson disease
title_sort validation of new diagnostic criteria for fatigue in patients with parkinson disease
topic Movement Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544823/
https://www.ncbi.nlm.nih.gov/pubmed/35587108
http://dx.doi.org/10.1111/ene.15411
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