Cargando…

Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial

OBJECTIVE: Rett syndrome (RTT), commonly caused by methyl‐CpG‐binding protein 2 (MECP2) pathogenic variants, has many comorbidities. Fifty to ninety percent of children with RTT have epilepsy, which is often drug‐resistant. Cannabidivarin (CBDV), a non‐hallucinogenic phytocannabinoid, has shown bene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hurley, Ellen N., Ellaway, Carolyn J., Johnson, Alexandra M., Truong, Linda, Gordon, Rebecca, Galettis, Peter, Martin, Jennifer H., Lawson, John A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544893/ https://www.ncbi.nlm.nih.gov/pubmed/35364618 http://dx.doi.org/10.1111/epi.17247

Ejemplares similares

Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
por: Amada, Naoki, et al.
Publicado: (2013)

Cannabis in epilepsy: From clinical practice to basic research focusing on the possible role of cannabidivarin
por: Morano, Alessandra, et al.
Publicado: (2016)

A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures
por: Brodie, Martin J., et al.
Publicado: (2021)

The Quality of Life in Girls with Rett Syndrome
por: Parisi, Lucia, et al.
Publicado: (2016)

Sleep Respiratory Disturbances in Girls with Rett Syndrome
por: Zhang, Xinyan, et al.
Publicado: (2022)

Rett syndrome with atrial tachycardia in a girl
por: Wang, Juanli, et al.
Publicado: (2022)

Multidisciplinary Management of Rett Syndrome: Twenty Years’ Experience
por: Vilvarajan, Sandra, et al.
Publicado: (2023)

Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions
por: Stone, Nicole L., et al.
Publicado: (2021)

Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin
por: Russo, Chiara, et al.
Publicado: (2021)

Antimicrobial Activity of Auranofin, Cannabidivarin, and Tolfenamic Acid against Multidrug-Resistant Neisseria gonorrhoeae
por: Yang, Fan, et al.
Publicado: (2022)

Epilepsy and genetic in Rett syndrome: A review
por: Operto, Francesca Felicia, et al.
Publicado: (2019)

Experience of Gastrostomy Using a Quality Care Framework: The Example of Rett Syndrome
por: Downs, Jenny, et al.
Publicado: (2014)

Management of epilepsy in patients with Rett syndrome: perspectives and considerations
por: Krajnc, Natalija
Publicado: (2015)

Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome
por: Thapa, Santosh, et al.
Publicado: (2021)

Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia
por: Wang, Xue, et al.
Publicado: (2022)

Reduced Volumetric Bone Mineral Density of the Spine in Adolescent Rett Girls with Scoliosis
por: Tsaknakis, Konstantinos, et al.
Publicado: (2022)

Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype
por: Williamson, Sarah L, et al.
Publicado: (2015)

Implementing telehealth support to increase physical activity in girls and women with Rett syndrome—ActivRett: protocol for a waitlist randomised controlled trial
por: Downs, Jenny, et al.
Publicado: (2020)

IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients
por: Pini, Giorgio, et al.
Publicado: (2012)

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells
por: Russo, Chiara, et al.
Publicado: (2018)

Effects of Combined Transcranial Direct Current Stimulation with Cognitive Training in Girls with Rett Syndrome
por: Fabio, Rosa Angela, et al.
Publicado: (2020)

Atypical Rett syndrome in a girl with mosaic triple X and MECP2 variant
por: Takahashi, Satoru, et al.
Publicado: (2020)

Abnormal spectral and scale-free properties of resting-state EEG in girls with Rett syndrome
por: Sysoeva, Olga, et al.
Publicado: (2023)

Diet and Nutritional Status of Polish Girls with Rett Syndrome—A Case-Control Study
por: Czerwonogrodzka-Senczyna, Aneta, et al.
Publicado: (2023)

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin
por: Pretzsch, Charlotte M., et al.
Publicado: (2021)

Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
por: Premoli, Marika, et al.
Publicado: (2023)

Atypical Rett Syndrome and Intractable Epilepsy With Novel GRIN2B Mutation
por: Kyriakopoulos, Paulina, et al.
Publicado: (2018)

Rett Syndrome Spectrum in Monogenic Developmental-Epileptic Encephalopathies and Epilepsies: A Review
por: Spagnoli, Carlotta, et al.
Publicado: (2021)

Visual Evoked Potentials in Rett Syndrome
por: Millichap, J. Gordon
Publicado: (2015)

Lower incidence of fracture after IV bisphosphonates in girls with Rett syndrome and severe bone fragility
por: Lambert, Anne-Sophie, et al.
Publicado: (2017)

Electroencephalographic spectral power as a marker of cortical function and disease severity in girls with Rett syndrome
por: Roche, Katherine J., et al.
Publicado: (2019)

Whole exome sequencing reveals a de novo missense variant in EEF1A2 in a Rett syndrome‐like patient
por: Kaur, Simranpreet, et al.
Publicado: (2019)

Anesthetic management of a Rett syndrome patient with apnea and epilepsy: a case report
por: Motomura, Yuka, et al.
Publicado: (2018)

Rett syndrome
por: Sitholey, Prabhat, et al.
Publicado: (2005)

Risk Factors for Late Diagnosis of Rett Syndrome
por: Millichap, J. Gordon
Publicado: (2015)

Profiling early socio-communicative development in five young girls with the preserved speech variant of Rett syndrome
por: Marschik, Peter B., et al.
Publicado: (2012)

Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats
por: Zamberletti, Erica, et al.
Publicado: (2019)

Rett mutations attenuate phase separation of MeCP2
por: Fan, Chunyan, et al.
Publicado: (2020)

Autonomic Characteristics of Sudden Unexpected Death in Epilepsy in Children—A Systematic Review of Studies and Their Relevance to the Management of Epilepsy in Rett Syndrome
por: Singh, Jatinder, et al.
Publicado: (2021)

Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study
por: Neul, Jeffrey L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p78b0g3mir0i6qrkksh898136q