Anti‐KIT monoclonal antibody CDX‐0159 induces profound and durable mast cell suppression in a healthy volunteer study

BACKGROUND: Mast cells (MC) are powerful inflammatory immune sentinel cells that drive numerous allergic, inflammatory, and pruritic disorders when activated. MC‐targeted therapies are approved in several disorders, yet many patients have limited benefit suggesting the need for approaches that more...

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Detalles Bibliográficos
Autores principales: Alvarado, Diego, Maurer, Marcus, Gedrich, Richard, Seibel, Scott B., Murphy, Michael B., Crew, Linda, Goldstein, Joel, Crocker, Andrea, Vitale, Laura A., Morani, Pamela A., Thomas, Lawrence J., Hawthorne, Thomas R., Keler, Tibor, Young, Diane, Crowley, Elizabeth, Kankam, Martin, Heath‐Chiozzi, Margo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9544977/
https://www.ncbi.nlm.nih.gov/pubmed/35184297
http://dx.doi.org/10.1111/all.15262

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