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Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease

The adaptive immune response of celiac disease (CeD) involves presentation of gluten peptides to CD4(+) T cells by transglutaminase 2 (TG2) specific B cells. This B‐cell/T‐cell crosstalk is facilitated by involvement of TG2:gluten peptide complexes that act principally in the form of enzyme‐substrat...

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Detalles Bibliográficos
Autores principales:	Amundsen, Sunniva F., Stamnaes, Jorunn, du Pré, Marie Fleur, Sollid, Ludvig M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Molecular immunology and signaling
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545004/ https://www.ncbi.nlm.nih.gov/pubmed/35715890 http://dx.doi.org/10.1002/eji.202249862

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