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Impaired renal clearance among Swedish adolescents born preterm

AIM: To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment. METHODS: Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16–...

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Autores principales: Skogastierna, Carin, Elfvin, Anders, Hansson, Sverker, Magnusson, Per, Swolin‐Eide, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545013/
https://www.ncbi.nlm.nih.gov/pubmed/35490381
http://dx.doi.org/10.1111/apa.16379
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author Skogastierna, Carin
Elfvin, Anders
Hansson, Sverker
Magnusson, Per
Swolin‐Eide, Diana
author_facet Skogastierna, Carin
Elfvin, Anders
Hansson, Sverker
Magnusson, Per
Swolin‐Eide, Diana
author_sort Skogastierna, Carin
collection PubMed
description AIM: To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment. METHODS: Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16–17 years of age with (51)Cr‐EDTA clearance. A comparison group (n = 26) was used. RESULTS: Most study participants (n = 13) had normal blood pressure; one individual had hypertension stage 1. All study participants had results within the reference interval for ionised calcium, parathyroid hormone, intact fibroblast growth factor‐23 and for urinary albumin‐to‐creatinine ratio. Four out of 16 participants (25%) had a (51)Cr‐EDTA clearance less than 90 ml/min/1.73 m(2), indicating a reduced kidney function. Measured (51)Cr‐EDTA clearance values were significantly lower in the study group than in the comparison group (p = 0.0012). Five study participants (31%) were referred for further investigations. CONCLUSION: Swedish children born before 28 gestational weeks have an increased risk of renal impairment later in life, suggesting that the kidney function in these individuals should be assessed, at least once, during adolescence.
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spelling pubmed-95450132022-10-14 Impaired renal clearance among Swedish adolescents born preterm Skogastierna, Carin Elfvin, Anders Hansson, Sverker Magnusson, Per Swolin‐Eide, Diana Acta Paediatr Original Articles & Brief Reports AIM: To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment. METHODS: Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16–17 years of age with (51)Cr‐EDTA clearance. A comparison group (n = 26) was used. RESULTS: Most study participants (n = 13) had normal blood pressure; one individual had hypertension stage 1. All study participants had results within the reference interval for ionised calcium, parathyroid hormone, intact fibroblast growth factor‐23 and for urinary albumin‐to‐creatinine ratio. Four out of 16 participants (25%) had a (51)Cr‐EDTA clearance less than 90 ml/min/1.73 m(2), indicating a reduced kidney function. Measured (51)Cr‐EDTA clearance values were significantly lower in the study group than in the comparison group (p = 0.0012). Five study participants (31%) were referred for further investigations. CONCLUSION: Swedish children born before 28 gestational weeks have an increased risk of renal impairment later in life, suggesting that the kidney function in these individuals should be assessed, at least once, during adolescence. John Wiley and Sons Inc. 2022-05-08 2022-09 /pmc/articles/PMC9545013/ /pubmed/35490381 http://dx.doi.org/10.1111/apa.16379 Text en © 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles & Brief Reports
Skogastierna, Carin
Elfvin, Anders
Hansson, Sverker
Magnusson, Per
Swolin‐Eide, Diana
Impaired renal clearance among Swedish adolescents born preterm
title Impaired renal clearance among Swedish adolescents born preterm
title_full Impaired renal clearance among Swedish adolescents born preterm
title_fullStr Impaired renal clearance among Swedish adolescents born preterm
title_full_unstemmed Impaired renal clearance among Swedish adolescents born preterm
title_short Impaired renal clearance among Swedish adolescents born preterm
title_sort impaired renal clearance among swedish adolescents born preterm
topic Original Articles & Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545013/
https://www.ncbi.nlm.nih.gov/pubmed/35490381
http://dx.doi.org/10.1111/apa.16379
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