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Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study
BACKGROUND: The Danish National Patient Registry holds data on hematological procedure codes including date and type of treatment from all hematological departments in Denmark. The validity of the hematological procedure codes remains to be clarified before they are used in epidemiological research....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545071/ https://www.ncbi.nlm.nih.gov/pubmed/35638368 http://dx.doi.org/10.1002/pds.5485 |
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author | Lauritsen, Tine Bichel Nørgaard, Jan Maxwell Christensen, Mathilde Egelund Dalton, Susanne Oksbjerg Østgård, Lene Sofie Granfeldt |
author_facet | Lauritsen, Tine Bichel Nørgaard, Jan Maxwell Christensen, Mathilde Egelund Dalton, Susanne Oksbjerg Østgård, Lene Sofie Granfeldt |
author_sort | Lauritsen, Tine Bichel |
collection | PubMed |
description | BACKGROUND: The Danish National Patient Registry holds data on hematological procedure codes including date and type of treatment from all hematological departments in Denmark. The validity of the hematological procedure codes remains to be clarified before they are used in epidemiological research. PATIENTS AND METHODS: Using the Danish Myelodysplastic Syndromes Database, we identified 897 patients diagnosed with myelodysplastic syndromes or chronic myelomonocytic leukemia treated at five Danish Hospitals between 1 January 2012 and 30 April 2019. From the Danish National Patient Registry, we ascertained information about hematological procedure codes and date of procedure registered on each patient and generated random samples. Using medical record review as the reference standard, we validated procedure codes in the Danish National Patient Registry and calculated positive predictive values (PPVs) with 95% confidence intervals (CIs) for each procedure code. RESULTS: A total of 523 medical records (99% of the total sample) were available for review. PPVs for specific procedure codes ranged from 71% to 100%. The overall PPV was 91% (95% CI: 88%–92%), reflecting PPVs of 95% (95% CI: 92%–97%) for low‐dose‐chemotherapy, 90% (95% CI: 81%–96%) for high‐dose chemotherapy, 99% (95% CI: 93%–100%) for allogeneic stem cell transplantation, 75% (95% CI: 62%–85%) for immuno‐modulating agents, 80% (95% CI: 74%–85%) for growth factors, and 99% (95% CI: 99%–100%) for bone marrow examination. The accuracy of coding was consistent across geographic regions and year of registration/coding. CONCLUSIONS: Hematological procedure codes reported to the Danish National Patient Registry had high PPVs and are suitable for epidemiological research. |
format | Online Article Text |
id | pubmed-9545071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95450712022-10-14 Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study Lauritsen, Tine Bichel Nørgaard, Jan Maxwell Christensen, Mathilde Egelund Dalton, Susanne Oksbjerg Østgård, Lene Sofie Granfeldt Pharmacoepidemiol Drug Saf Original Articles BACKGROUND: The Danish National Patient Registry holds data on hematological procedure codes including date and type of treatment from all hematological departments in Denmark. The validity of the hematological procedure codes remains to be clarified before they are used in epidemiological research. PATIENTS AND METHODS: Using the Danish Myelodysplastic Syndromes Database, we identified 897 patients diagnosed with myelodysplastic syndromes or chronic myelomonocytic leukemia treated at five Danish Hospitals between 1 January 2012 and 30 April 2019. From the Danish National Patient Registry, we ascertained information about hematological procedure codes and date of procedure registered on each patient and generated random samples. Using medical record review as the reference standard, we validated procedure codes in the Danish National Patient Registry and calculated positive predictive values (PPVs) with 95% confidence intervals (CIs) for each procedure code. RESULTS: A total of 523 medical records (99% of the total sample) were available for review. PPVs for specific procedure codes ranged from 71% to 100%. The overall PPV was 91% (95% CI: 88%–92%), reflecting PPVs of 95% (95% CI: 92%–97%) for low‐dose‐chemotherapy, 90% (95% CI: 81%–96%) for high‐dose chemotherapy, 99% (95% CI: 93%–100%) for allogeneic stem cell transplantation, 75% (95% CI: 62%–85%) for immuno‐modulating agents, 80% (95% CI: 74%–85%) for growth factors, and 99% (95% CI: 99%–100%) for bone marrow examination. The accuracy of coding was consistent across geographic regions and year of registration/coding. CONCLUSIONS: Hematological procedure codes reported to the Danish National Patient Registry had high PPVs and are suitable for epidemiological research. John Wiley & Sons, Inc. 2022-06-20 2022-09 /pmc/articles/PMC9545071/ /pubmed/35638368 http://dx.doi.org/10.1002/pds.5485 Text en © 2022 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Lauritsen, Tine Bichel Nørgaard, Jan Maxwell Christensen, Mathilde Egelund Dalton, Susanne Oksbjerg Østgård, Lene Sofie Granfeldt Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title | Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title_full | Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title_fullStr | Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title_full_unstemmed | Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title_short | Positive predictive values of hematological procedure codes in the Danish National Patient Registry—A population‐based validation study |
title_sort | positive predictive values of hematological procedure codes in the danish national patient registry—a population‐based validation study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545071/ https://www.ncbi.nlm.nih.gov/pubmed/35638368 http://dx.doi.org/10.1002/pds.5485 |
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