DNA methylation can alter CRISPR/Cas9 editing frequency and DNA repair outcome in a target‐specific manner

The impact of epigenetic modifications on the efficacy of CRISPR/Cas9‐mediated double‐stranded DNA breaks and subsequent DNA repair is poorly understood, especially in plants. In this study, we investigated the effect of the level of cytosine methylation on the outcome of CRISPR/Cas9‐induced mutatio...

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Detalles Bibliográficos
Autores principales: Přibylová, Adéla, Fischer, Lukáš, Pyott, Douglas E., Bassett, Andrew, Molnar, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545110/
https://www.ncbi.nlm.nih.gov/pubmed/35524464
http://dx.doi.org/10.1111/nph.18212

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