Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline

Bedaquiline is a crucial medicine in the global fight against tuberculosis, yet its high price places it out of reach for many patients. Herein, we describe improvements to the key industrial lithiation‐addition sequence that enable a higher yielding and therefore more economical synthesis of bedaqu...

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Detalles Bibliográficos
Autores principales: Mear, Sarah Jane, Lucas, Tobias, Ahlqvist, Grace P., Robey, Juliana M. S., Dietz, Jule‐Philipp, Khairnar, Pankaj V., Maity, Sanjay, Williams, Corshai L., Snead, David R., Nelson, Ryan C., Opatz, Till, Jamison, Timothy F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545417/
https://www.ncbi.nlm.nih.gov/pubmed/35675114
http://dx.doi.org/10.1002/chem.202201311

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