BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication fork protection. Nonsense or frameshift mutations...

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Detalles Bibliográficos
Autores principales: Jimenez-Sainz, Judit, Mathew, Joshua, Moore, Gemma, Lahiri, Sudipta, Garbarino, Jennifer, Eder, Joseph P, Rothenberg, Eli, Jensen, Ryan B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545528/
https://www.ncbi.nlm.nih.gov/pubmed/36098506
http://dx.doi.org/10.7554/eLife.79183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545528/
https://www.ncbi.nlm.nih.gov/pubmed/36098506
http://dx.doi.org/10.7554/eLife.79183

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