Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit in‐vitro seeded aggregation and toxicity

Nanobodies (Nbs), the single‐domain antigen‐binding fragments of dromedary heavy‐chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, solubility and stability. Here, we constructed an immune nanobody library specific...

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Detalles Bibliográficos
Autores principales: Hmila, Issam, Vaikath, Nishant N., Majbour, Nour K., Erskine, Daniel, Sudhakaran, Indulekha P., Gupta, Vijay, Ghanem, Simona S., Islam, Zeyaul, Emara, Mohamed M., Abdesselem, Houari B., Kolatkar, Prasanna R., Achappa, Devaya K., Vinardell, Tatiana, El‐Agnaf, Omar M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545584/
https://www.ncbi.nlm.nih.gov/pubmed/35090199
http://dx.doi.org/10.1111/febs.16376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545584/
https://www.ncbi.nlm.nih.gov/pubmed/35090199
http://dx.doi.org/10.1111/febs.16376

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