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Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool

Asymmetric cell division is a key tumor suppressor mechanism that prevents the uncontrolled expansion of the stem cell (SC) compartment by generating daughter cells with alternative fates: one retains SC identity and enters quiescence and the other becomes a rapidly proliferating and differentiating...

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Detalles Bibliográficos
Autores principales:	Filippone, Maria Grazia, Freddi, Stefano, Zecchini, Silvia, Restelli, Silvia, Colaluca, Ivan Nicola, Bertalot, Giovanni, Pece, Salvatore, Tosoni, Daniela, Di Fiore, Pier Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545709/ https://www.ncbi.nlm.nih.gov/pubmed/36200956 http://dx.doi.org/10.1083/jcb.202112001

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