Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes

Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can a...

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Autores principales: Gutiérrez‐González, Alejandro, Destito, Paolo, Couceiro, José R., Pérez‐González, Cibran, López, Fernando, Mascareñas, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545742/
https://www.ncbi.nlm.nih.gov/pubmed/33971072
http://dx.doi.org/10.1002/anie.202103645
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author Gutiérrez‐González, Alejandro
Destito, Paolo
Couceiro, José R.
Pérez‐González, Cibran
López, Fernando
Mascareñas, José L.
author_facet Gutiérrez‐González, Alejandro
Destito, Paolo
Couceiro, José R.
Pérez‐González, Cibran
López, Fernando
Mascareñas, José L.
author_sort Gutiérrez‐González, Alejandro
collection PubMed
description Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium‐based technology and the standard copper‐catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal.
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spelling pubmed-95457422022-10-14 Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes Gutiérrez‐González, Alejandro Destito, Paolo Couceiro, José R. Pérez‐González, Cibran López, Fernando Mascareñas, José L. Angew Chem Int Ed Engl Research Articles Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium‐based technology and the standard copper‐catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal. John Wiley and Sons Inc. 2021-06-16 2021-07-12 /pmc/articles/PMC9545742/ /pubmed/33971072 http://dx.doi.org/10.1002/anie.202103645 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gutiérrez‐González, Alejandro
Destito, Paolo
Couceiro, José R.
Pérez‐González, Cibran
López, Fernando
Mascareñas, José L.
Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_full Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_fullStr Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_full_unstemmed Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_short Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_sort bioorthogonal azide–thioalkyne cycloaddition catalyzed by photoactivatable ruthenium(ii) complexes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545742/
https://www.ncbi.nlm.nih.gov/pubmed/33971072
http://dx.doi.org/10.1002/anie.202103645
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