Cargando…

Role of hypoxia in the tumor microenvironment and targeted therapy

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid tumors. As a current research hotspot in the TME, hypoxia is expected to become a key element to break through the bottleneck of tumor treatment. More and more research results show that a variety of biological b...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Gaoqi, Wu, Kaiwen, Li, Hao, Xia, Demeng, He, Tianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545774/
https://www.ncbi.nlm.nih.gov/pubmed/36212414
http://dx.doi.org/10.3389/fonc.2022.961637
_version_ 1784804894493900800
author Chen, Gaoqi
Wu, Kaiwen
Li, Hao
Xia, Demeng
He, Tianlin
author_facet Chen, Gaoqi
Wu, Kaiwen
Li, Hao
Xia, Demeng
He, Tianlin
author_sort Chen, Gaoqi
collection PubMed
description Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid tumors. As a current research hotspot in the TME, hypoxia is expected to become a key element to break through the bottleneck of tumor treatment. More and more research results show that a variety of biological behaviors of tumor cells are affected by many factors in TME which are closely related to hypoxia. In order to inhibiting the immune response in TME, hypoxia plays an important role in tumor cell metabolism and anti-apoptosis. Therefore, exploring the molecular mechanism of hypoxia mediated malignant tumor behavior and therapeutic targets is expected to provide new ideas for anti-tumor therapy. In this review, we discussed the effects of hypoxia on tumor behavior and its interaction with TME from the perspectives of immune cells, cell metabolism, oxidative stress and hypoxia inducible factor (HIF), and listed the therapeutic targets or signal pathways found so far. Finally, we summarize the current therapies targeting hypoxia, such as glycolysis inhibitors, anti-angiogenesis drugs, HIF inhibitors, hypoxia-activated prodrugs, and hyperbaric medicine.
format Online
Article
Text
id pubmed-9545774
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95457742022-10-08 Role of hypoxia in the tumor microenvironment and targeted therapy Chen, Gaoqi Wu, Kaiwen Li, Hao Xia, Demeng He, Tianlin Front Oncol Oncology Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid tumors. As a current research hotspot in the TME, hypoxia is expected to become a key element to break through the bottleneck of tumor treatment. More and more research results show that a variety of biological behaviors of tumor cells are affected by many factors in TME which are closely related to hypoxia. In order to inhibiting the immune response in TME, hypoxia plays an important role in tumor cell metabolism and anti-apoptosis. Therefore, exploring the molecular mechanism of hypoxia mediated malignant tumor behavior and therapeutic targets is expected to provide new ideas for anti-tumor therapy. In this review, we discussed the effects of hypoxia on tumor behavior and its interaction with TME from the perspectives of immune cells, cell metabolism, oxidative stress and hypoxia inducible factor (HIF), and listed the therapeutic targets or signal pathways found so far. Finally, we summarize the current therapies targeting hypoxia, such as glycolysis inhibitors, anti-angiogenesis drugs, HIF inhibitors, hypoxia-activated prodrugs, and hyperbaric medicine. Frontiers Media S.A. 2022-09-23 /pmc/articles/PMC9545774/ /pubmed/36212414 http://dx.doi.org/10.3389/fonc.2022.961637 Text en Copyright © 2022 Chen, Wu, Li, Xia and He https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Gaoqi
Wu, Kaiwen
Li, Hao
Xia, Demeng
He, Tianlin
Role of hypoxia in the tumor microenvironment and targeted therapy
title Role of hypoxia in the tumor microenvironment and targeted therapy
title_full Role of hypoxia in the tumor microenvironment and targeted therapy
title_fullStr Role of hypoxia in the tumor microenvironment and targeted therapy
title_full_unstemmed Role of hypoxia in the tumor microenvironment and targeted therapy
title_short Role of hypoxia in the tumor microenvironment and targeted therapy
title_sort role of hypoxia in the tumor microenvironment and targeted therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545774/
https://www.ncbi.nlm.nih.gov/pubmed/36212414
http://dx.doi.org/10.3389/fonc.2022.961637
work_keys_str_mv AT chengaoqi roleofhypoxiainthetumormicroenvironmentandtargetedtherapy
AT wukaiwen roleofhypoxiainthetumormicroenvironmentandtargetedtherapy
AT lihao roleofhypoxiainthetumormicroenvironmentandtargetedtherapy
AT xiademeng roleofhypoxiainthetumormicroenvironmentandtargetedtherapy
AT hetianlin roleofhypoxiainthetumormicroenvironmentandtargetedtherapy