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Cell Surface Calcium‐Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca(2+) Sensing but Not G Protein Interaction

The calcium‐sensing receptor is a homodimeric class C G protein‐coupled receptor (GPCR) that senses extracellular Ca(2+) (Ca(2+) (o)) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein‐dependent signaling via twin Cysteine‐rich domains linked to transmembrane heptahelical...

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Detalles Bibliográficos
Autores principales:	Goolam, Mahvash A., Brown, Alice P., Edwards, Kimberly T., Gregory, Karen J., Leach, Katie, Conigrave, Arthur D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545990/ https://www.ncbi.nlm.nih.gov/pubmed/35848051 http://dx.doi.org/10.1002/jbmr.4651

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