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Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort

BACKGROUND: Acral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiolo...

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Autores principales: Assan, F., Husson, B., Hegazy, S., Seneschal, J., Aubin, F., Mahé, E., Jullien, D., Sbidian, E., D'Incan, M., Conrad, C., Brenaut, E., Girard, C., Richard, M.A., Bachelez, H., Viguier, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546063/
https://www.ncbi.nlm.nih.gov/pubmed/35366356
http://dx.doi.org/10.1111/jdv.18127
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author Assan, F.
Husson, B.
Hegazy, S.
Seneschal, J.
Aubin, F.
Mahé, E.
Jullien, D.
Sbidian, E.
D'Incan, M.
Conrad, C.
Brenaut, E.
Girard, C.
Richard, M.A.
Bachelez, H.
Viguier, M.
author_facet Assan, F.
Husson, B.
Hegazy, S.
Seneschal, J.
Aubin, F.
Mahé, E.
Jullien, D.
Sbidian, E.
D'Incan, M.
Conrad, C.
Brenaut, E.
Girard, C.
Richard, M.A.
Bachelez, H.
Viguier, M.
author_sort Assan, F.
collection PubMed
description BACKGROUND: Acral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP. OBJECTIVES: We aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort. METHODS: In this multicentre national retrospective cohort study, we compared the epidemiological characteristics, comorbidities and psoriasis characteristics of patients with PPP and ACH. RESULTS: A total of 234 patients were included: 203 (87%) with PPP, 18 (8%) with ACH and 13 (6%) with both, according to 2017 ERASPEN criteria. As compared with ACH, PPP was associated with female sex, smoking activity and higher median BMI (P = 0.01, P = 0.02 and P = 0.05 respectively). A family background of psoriasis was more frequent in PPP than ACH. Age of onset of palmoplantar disease was similar between PPP and ACH patients, median age 44 and 48 years respectively. Peripheral joint inflammatory involvement was the only rheumatic disease associated with ACH. The association with another psoriasis type was similar in PPP and ACH (57.6% and 61.1% respectively). CONCLUSION: Our study confirms in a large PPP cohort the predominance of females and a high prevalence of smoking and elevated body mass index but also shows an association of these features in PPP as compared with ACH. In addition, it highlights peripheral arthritis as the only arthritis endotype associated with ACH. Increased knowledge of the immunogenetic backgrounds underlying these two entities is warranted to better stratify pustular psoriasis or psoriasis‐like entities for precision medicine.
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spelling pubmed-95460632022-10-14 Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort Assan, F. Husson, B. Hegazy, S. Seneschal, J. Aubin, F. Mahé, E. Jullien, D. Sbidian, E. D'Incan, M. Conrad, C. Brenaut, E. Girard, C. Richard, M.A. Bachelez, H. Viguier, M. J Eur Acad Dermatol Venereol Jeadv September Issue BACKGROUND: Acral pustular disease within the pustular psoriasis/psoriasis‐like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP. OBJECTIVES: We aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort. METHODS: In this multicentre national retrospective cohort study, we compared the epidemiological characteristics, comorbidities and psoriasis characteristics of patients with PPP and ACH. RESULTS: A total of 234 patients were included: 203 (87%) with PPP, 18 (8%) with ACH and 13 (6%) with both, according to 2017 ERASPEN criteria. As compared with ACH, PPP was associated with female sex, smoking activity and higher median BMI (P = 0.01, P = 0.02 and P = 0.05 respectively). A family background of psoriasis was more frequent in PPP than ACH. Age of onset of palmoplantar disease was similar between PPP and ACH patients, median age 44 and 48 years respectively. Peripheral joint inflammatory involvement was the only rheumatic disease associated with ACH. The association with another psoriasis type was similar in PPP and ACH (57.6% and 61.1% respectively). CONCLUSION: Our study confirms in a large PPP cohort the predominance of females and a high prevalence of smoking and elevated body mass index but also shows an association of these features in PPP as compared with ACH. In addition, it highlights peripheral arthritis as the only arthritis endotype associated with ACH. Increased knowledge of the immunogenetic backgrounds underlying these two entities is warranted to better stratify pustular psoriasis or psoriasis‐like entities for precision medicine. John Wiley and Sons Inc. 2022-04-12 2022-09 /pmc/articles/PMC9546063/ /pubmed/35366356 http://dx.doi.org/10.1111/jdv.18127 Text en © 2022 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Jeadv September Issue
Assan, F.
Husson, B.
Hegazy, S.
Seneschal, J.
Aubin, F.
Mahé, E.
Jullien, D.
Sbidian, E.
D'Incan, M.
Conrad, C.
Brenaut, E.
Girard, C.
Richard, M.A.
Bachelez, H.
Viguier, M.
Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title_full Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title_fullStr Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title_full_unstemmed Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title_short Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort
title_sort palmoplantar pustulosis and acrodermatitis continua of hallopeau: demographic and clinical comparative study in a large multicentre cohort
topic Jeadv September Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546063/
https://www.ncbi.nlm.nih.gov/pubmed/35366356
http://dx.doi.org/10.1111/jdv.18127
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