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Extending the Continual Reassessment Method to accommodate step‐up dosing in Phase I trials
The Continual Reassessment Method (CRM) was developed for Phase I trials to identify a maximum‐tolerated dose of an agent using a design in which each participant is treated with a single administration of the agent. We propose an extension of the CRM in which participants receive multiple administr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546169/ https://www.ncbi.nlm.nih.gov/pubmed/35662077 http://dx.doi.org/10.1002/sim.9487 |