Production of a high purity, C‐tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions

Virus‐like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the method used for the production of R21, a VLP‐based anti‐sporozoite malaria vaccine, under current Clinical Good Manufacturing Practice regulati...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Ekta, Brod, Florian, Angell‐Manning, Philip, Green, Nicola, Tarrant, Richard D., Detmers, Frank J., Bolam, Emma J., Baleanu, Ioana N., Hobson, Mark, Whale, Gary, Morris, Susan J., Ashfield, Rebecca, Gilbert, Sarah C., Jin, Jing, Draper, Simon J., Moyle, Sarah P., Berrie, Eleanor L., Hill, Adrian V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546177/
https://www.ncbi.nlm.nih.gov/pubmed/35822551
http://dx.doi.org/10.1002/bit.28181

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