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Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study
The association between childhood trauma exposure and risk of developing psychopathology may in part be mediated by the effects of chronic stress on dopaminergic neurotransmission. However, little is known about the differential effects of distinct trauma types on reward processing, particularly in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546243/ https://www.ncbi.nlm.nih.gov/pubmed/35434795 http://dx.doi.org/10.1002/jnr.25051 |
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author | Hendrikse, Chanellé Juanita du Plessis, Stéfan Luckhoff, Hilmar Klaus Vink, Matthijs van den Heuvel, Leigh Luella Scheffler, Freda Phahladira, Lebogang Smit, Retha Asmal, Laila Seedat, Soraya Emsley, Robin |
author_facet | Hendrikse, Chanellé Juanita du Plessis, Stéfan Luckhoff, Hilmar Klaus Vink, Matthijs van den Heuvel, Leigh Luella Scheffler, Freda Phahladira, Lebogang Smit, Retha Asmal, Laila Seedat, Soraya Emsley, Robin |
author_sort | Hendrikse, Chanellé Juanita |
collection | PubMed |
description | The association between childhood trauma exposure and risk of developing psychopathology may in part be mediated by the effects of chronic stress on dopaminergic neurotransmission. However, little is known about the differential effects of distinct trauma types on reward processing, particularly in adults without concurrent medical or psychiatric disorders. We examined the association of childhood trauma exposure, including the differential effects of abuse and neglect, with reward processing in healthy adults (n = 114). Functional magnetic resonance imaging during a monetary incentive delay task was used to assess neural activity in the ventral striatum and orbitofrontal cortex in relation to reward anticipation and reward outcome, respectively. Exposure to childhood trauma, including abuse and neglect, was assessed using the Childhood Trauma Questionnaire‐Short Form. We found a significant effect for abuse on ventral striatal activation during reward anticipation, adjusting for age, sex, scanner site, educational level, and household monthly income. There were no effects for abuse or neglect, independently or combined, on orbitofrontal cortex activation during reward outcome. Our findings suggest differential effects of childhood abuse on ventral striatum activation during reward anticipation in healthy adults. |
format | Online Article Text |
id | pubmed-9546243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95462432022-10-14 Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study Hendrikse, Chanellé Juanita du Plessis, Stéfan Luckhoff, Hilmar Klaus Vink, Matthijs van den Heuvel, Leigh Luella Scheffler, Freda Phahladira, Lebogang Smit, Retha Asmal, Laila Seedat, Soraya Emsley, Robin J Neurosci Res Research Articles The association between childhood trauma exposure and risk of developing psychopathology may in part be mediated by the effects of chronic stress on dopaminergic neurotransmission. However, little is known about the differential effects of distinct trauma types on reward processing, particularly in adults without concurrent medical or psychiatric disorders. We examined the association of childhood trauma exposure, including the differential effects of abuse and neglect, with reward processing in healthy adults (n = 114). Functional magnetic resonance imaging during a monetary incentive delay task was used to assess neural activity in the ventral striatum and orbitofrontal cortex in relation to reward anticipation and reward outcome, respectively. Exposure to childhood trauma, including abuse and neglect, was assessed using the Childhood Trauma Questionnaire‐Short Form. We found a significant effect for abuse on ventral striatal activation during reward anticipation, adjusting for age, sex, scanner site, educational level, and household monthly income. There were no effects for abuse or neglect, independently or combined, on orbitofrontal cortex activation during reward outcome. Our findings suggest differential effects of childhood abuse on ventral striatum activation during reward anticipation in healthy adults. John Wiley and Sons Inc. 2022-04-17 2022-07 /pmc/articles/PMC9546243/ /pubmed/35434795 http://dx.doi.org/10.1002/jnr.25051 Text en © 2022 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Hendrikse, Chanellé Juanita du Plessis, Stéfan Luckhoff, Hilmar Klaus Vink, Matthijs van den Heuvel, Leigh Luella Scheffler, Freda Phahladira, Lebogang Smit, Retha Asmal, Laila Seedat, Soraya Emsley, Robin Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title | Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title_full | Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title_fullStr | Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title_full_unstemmed | Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title_short | Childhood trauma exposure and reward processing in healthy adults: A functional neuroimaging study |
title_sort | childhood trauma exposure and reward processing in healthy adults: a functional neuroimaging study |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546243/ https://www.ncbi.nlm.nih.gov/pubmed/35434795 http://dx.doi.org/10.1002/jnr.25051 |
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