A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell‐of‐origin dependent effects of H3K27M

Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are candidate cells‐of‐origin for DMG, yet there is no genetically engineered mouse mode...

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Detalles Bibliográficos
Autores principales: Tomita, Yusuke, Shimazu, Yosuke, Somasundaram, Agila, Tanaka, Yoshihiro, Takata, Nozomu, Ishi, Yukitomo, Gadd, Samantha, Hashizume, Rintaro, Angione, Angelo, Pinero, Gonzalo, Hambardzumyan, Dolores, Brat, Daniel J., Hoeman, Christine M., Becher, Oren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546478/
https://www.ncbi.nlm.nih.gov/pubmed/35524725
http://dx.doi.org/10.1002/glia.24189

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