Alcohols as Alkylating Agents in the Cation‐Induced Formation of Nitrogen Heterocycles

A Ti(Oi‐Pr)(4) promoted 5‐ or 6‐endo‐trig cyclisation to make nitrogen heterocycles is presented. The utilisation of HFIP as a key solvent enables the stereoselective preparation of di‐ & tri‐substituted pyrrolidines and piperidines while forming a new C−C bond at the same time. The process is t...

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Detalles Bibliográficos
Autores principales: Cox, Lydia, Zhu, Yuxiang, Smith, Philip J., Christensen, Kirsten E., Sidera Portela, Mireia, Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546487/
https://www.ncbi.nlm.nih.gov/pubmed/35770710
http://dx.doi.org/10.1002/anie.202206800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546487/
https://www.ncbi.nlm.nih.gov/pubmed/35770710
http://dx.doi.org/10.1002/anie.202206800

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