Melanoma secretion of transforming growth factor‐β2 leads to loss of epidermal AMBRA1 threatening epidermal integrity and facilitating tumour ulceration

BACKGROUND: For patients with early American Joint Committee on Cancer (AJCC)‐stage melanoma the combined loss of the autophagy regulatory protein AMBRA1 and the terminal differentiation marker loricrin in the peritumoral epidermis is associated with a significantly increased risk of metastasis. OBJ...

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Detalles Bibliográficos
Autores principales: Cosgarea, I., McConnell, A.T., Ewen, T., Tang, D., Hill, D.S., Anagnostou, M., Elias, M., Ellis, R.A., Murray, A., Spender, L.C., Giglio, P., Gagliardi, M., Greenwood, A., Piacentini, M., Inman, G.J., Fimia, G.M., Corazzari, M., Armstrong, J.L., Lovat, P.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546516/
https://www.ncbi.nlm.nih.gov/pubmed/34773645
http://dx.doi.org/10.1111/bjd.20889

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