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Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in puta...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546536/ https://www.ncbi.nlm.nih.gov/pubmed/36166477 http://dx.doi.org/10.1073/pnas.2121024119 |
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author | Bañuelos, Mayra M. Zavaleta, Yuómi Jhony A. Roldan, Alennie Reyes, Rochelle-Jan Guardado, Miguel Chavez Rojas, Berenice Nyein, Thet Rodriguez Vega, Ana Santos, Maribel Huerta-Sanchez, Emilia Rohlfs, Rori V. |
author_facet | Bañuelos, Mayra M. Zavaleta, Yuómi Jhony A. Roldan, Alennie Reyes, Rochelle-Jan Guardado, Miguel Chavez Rojas, Berenice Nyein, Thet Rodriguez Vega, Ana Santos, Maribel Huerta-Sanchez, Emilia Rohlfs, Rori V. |
author_sort | Bañuelos, Mayra M. |
collection | PubMed |
description | A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in putative gene deserts to avoid forensic profiles revealing protected medical information. We revisit that assumption, investigating whether forensic genetic profiles reveal information about gene-expression variation or potential medical information. We find six significant correlations (false discovery rate = 0.23) between the forensic STRs and the expression levels of neighboring genes in lymphoblastoid cell lines. We explore possible mechanisms for these associations, showing evidence compatible with forensic STRs causing expression variation or being in linkage disequilibrium with a causal locus in three cases and weaker or potentially spurious associations in the other three cases. Together, these results suggest that forensic genetic loci may reveal expression levels and, perhaps, medical information. |
format | Online Article Text |
id | pubmed-9546536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-95465362022-10-08 Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy Bañuelos, Mayra M. Zavaleta, Yuómi Jhony A. Roldan, Alennie Reyes, Rochelle-Jan Guardado, Miguel Chavez Rojas, Berenice Nyein, Thet Rodriguez Vega, Ana Santos, Maribel Huerta-Sanchez, Emilia Rohlfs, Rori V. Proc Natl Acad Sci U S A Biological Sciences A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in putative gene deserts to avoid forensic profiles revealing protected medical information. We revisit that assumption, investigating whether forensic genetic profiles reveal information about gene-expression variation or potential medical information. We find six significant correlations (false discovery rate = 0.23) between the forensic STRs and the expression levels of neighboring genes in lymphoblastoid cell lines. We explore possible mechanisms for these associations, showing evidence compatible with forensic STRs causing expression variation or being in linkage disequilibrium with a causal locus in three cases and weaker or potentially spurious associations in the other three cases. Together, these results suggest that forensic genetic loci may reveal expression levels and, perhaps, medical information. National Academy of Sciences 2022-09-27 2022-10-04 /pmc/articles/PMC9546536/ /pubmed/36166477 http://dx.doi.org/10.1073/pnas.2121024119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Bañuelos, Mayra M. Zavaleta, Yuómi Jhony A. Roldan, Alennie Reyes, Rochelle-Jan Guardado, Miguel Chavez Rojas, Berenice Nyein, Thet Rodriguez Vega, Ana Santos, Maribel Huerta-Sanchez, Emilia Rohlfs, Rori V. Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title | Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title_full | Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title_fullStr | Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title_full_unstemmed | Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title_short | Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
title_sort | associations between forensic loci and expression levels of neighboring genes may compromise medical privacy |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546536/ https://www.ncbi.nlm.nih.gov/pubmed/36166477 http://dx.doi.org/10.1073/pnas.2121024119 |
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