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Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy

A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in puta...

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Autores principales: Bañuelos, Mayra M., Zavaleta, Yuómi Jhony A., Roldan, Alennie, Reyes, Rochelle-Jan, Guardado, Miguel, Chavez Rojas, Berenice, Nyein, Thet, Rodriguez Vega, Ana, Santos, Maribel, Huerta-Sanchez, Emilia, Rohlfs, Rori V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546536/
https://www.ncbi.nlm.nih.gov/pubmed/36166477
http://dx.doi.org/10.1073/pnas.2121024119
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author Bañuelos, Mayra M.
Zavaleta, Yuómi Jhony A.
Roldan, Alennie
Reyes, Rochelle-Jan
Guardado, Miguel
Chavez Rojas, Berenice
Nyein, Thet
Rodriguez Vega, Ana
Santos, Maribel
Huerta-Sanchez, Emilia
Rohlfs, Rori V.
author_facet Bañuelos, Mayra M.
Zavaleta, Yuómi Jhony A.
Roldan, Alennie
Reyes, Rochelle-Jan
Guardado, Miguel
Chavez Rojas, Berenice
Nyein, Thet
Rodriguez Vega, Ana
Santos, Maribel
Huerta-Sanchez, Emilia
Rohlfs, Rori V.
author_sort Bañuelos, Mayra M.
collection PubMed
description A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in putative gene deserts to avoid forensic profiles revealing protected medical information. We revisit that assumption, investigating whether forensic genetic profiles reveal information about gene-expression variation or potential medical information. We find six significant correlations (false discovery rate = 0.23) between the forensic STRs and the expression levels of neighboring genes in lymphoblastoid cell lines. We explore possible mechanisms for these associations, showing evidence compatible with forensic STRs causing expression variation or being in linkage disequilibrium with a causal locus in three cases and weaker or potentially spurious associations in the other three cases. Together, these results suggest that forensic genetic loci may reveal expression levels and, perhaps, medical information.
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spelling pubmed-95465362022-10-08 Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy Bañuelos, Mayra M. Zavaleta, Yuómi Jhony A. Roldan, Alennie Reyes, Rochelle-Jan Guardado, Miguel Chavez Rojas, Berenice Nyein, Thet Rodriguez Vega, Ana Santos, Maribel Huerta-Sanchez, Emilia Rohlfs, Rori V. Proc Natl Acad Sci U S A Biological Sciences A set of 20 short tandem repeats (STRs) is used by the US criminal justice system to identify suspects and to maintain a database of genetic profiles for individuals who have been previously convicted or arrested. Some of these STRs were identified in the 1990s, with a preference for markers in putative gene deserts to avoid forensic profiles revealing protected medical information. We revisit that assumption, investigating whether forensic genetic profiles reveal information about gene-expression variation or potential medical information. We find six significant correlations (false discovery rate = 0.23) between the forensic STRs and the expression levels of neighboring genes in lymphoblastoid cell lines. We explore possible mechanisms for these associations, showing evidence compatible with forensic STRs causing expression variation or being in linkage disequilibrium with a causal locus in three cases and weaker or potentially spurious associations in the other three cases. Together, these results suggest that forensic genetic loci may reveal expression levels and, perhaps, medical information. National Academy of Sciences 2022-09-27 2022-10-04 /pmc/articles/PMC9546536/ /pubmed/36166477 http://dx.doi.org/10.1073/pnas.2121024119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Bañuelos, Mayra M.
Zavaleta, Yuómi Jhony A.
Roldan, Alennie
Reyes, Rochelle-Jan
Guardado, Miguel
Chavez Rojas, Berenice
Nyein, Thet
Rodriguez Vega, Ana
Santos, Maribel
Huerta-Sanchez, Emilia
Rohlfs, Rori V.
Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title_full Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title_fullStr Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title_full_unstemmed Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title_short Associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
title_sort associations between forensic loci and expression levels of neighboring genes may compromise medical privacy
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546536/
https://www.ncbi.nlm.nih.gov/pubmed/36166477
http://dx.doi.org/10.1073/pnas.2121024119
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