Human sperm TMEM95 binds eggs and facilitates membrane fusion

Tmem95 encodes a sperm acrosomal membrane protein, whose knockout has a male-specific sterility phenotype in mice. Tmem95 knockout murine sperm can bind to, but do not fuse with, eggs. How TMEM95 plays a role in membrane fusion of sperm and eggs has remained elusive. Here, we utilize a sperm penetra...

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Detalles Bibliográficos
Autores principales: Tang, Shaogeng, Lu, Yonggang, Skinner, Will M., Sanyal, Mrinmoy, Lishko, Polina V., Ikawa, Masahito, Kim, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546558/
https://www.ncbi.nlm.nih.gov/pubmed/36161911
http://dx.doi.org/10.1073/pnas.2207805119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546558/
https://www.ncbi.nlm.nih.gov/pubmed/36161911
http://dx.doi.org/10.1073/pnas.2207805119

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