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Reduced Satb1 expression predisposes CD4(+) T conventional cells to Treg suppression and promotes transplant survival

Limiting CD4(+) T cell responses is important to prevent solid organ transplant rejection. In a mouse model of costimulation blockade-dependent cardiac allograft tolerance, we previously reported that alloreactive CD4(+) conventional T cells (Tconvs) develop dysfunction, losing proliferative capacit...

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Detalles Bibliográficos
Autores principales:	Gupta, Pawan K., Allocco, Jennifer B., Fraipont, Jane M., McKeague, Michelle L., Wang, Peter, Andrade, Michael S., McIntosh, Christine, Chen, Luqiu, Wang, Ying, Li, Yan, Andrade, Jorge, Conejo-Garcia, José R., Chong, Anita S., Alegre, Maria-Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546564/ https://www.ncbi.nlm.nih.gov/pubmed/36161903 http://dx.doi.org/10.1073/pnas.2205062119

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