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Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag KG
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546583/ https://www.ncbi.nlm.nih.gov/pubmed/36206761 http://dx.doi.org/10.1055/a-1909-1922 |
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author | Zhu, Jing Jiang, Shuai Jiang, Xiaohong Luo, Kaiming Huang, Xiaolin Hua, Fei |
author_facet | Zhu, Jing Jiang, Shuai Jiang, Xiaohong Luo, Kaiming Huang, Xiaolin Hua, Fei |
author_sort | Zhu, Jing |
collection | PubMed |
description | Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed. |
format | Online Article Text |
id | pubmed-9546583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-95465832022-10-08 Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis Zhu, Jing Jiang, Shuai Jiang, Xiaohong Luo, Kaiming Huang, Xiaolin Hua, Fei Horm Metab Res Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed. Georg Thieme Verlag KG 2022-10-07 /pmc/articles/PMC9546583/ /pubmed/36206761 http://dx.doi.org/10.1055/a-1909-1922 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited. |
spellingShingle | Zhu, Jing Jiang, Shuai Jiang, Xiaohong Luo, Kaiming Huang, Xiaolin Hua, Fei Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis |
title | Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
Mellitus: A Systematic Review and Meta-Analysis |
title_full | Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
Mellitus: A Systematic Review and Meta-Analysis |
title_fullStr | Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
Mellitus: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
Mellitus: A Systematic Review and Meta-Analysis |
title_short | Association Of Blood Lipocalin-2 Levels with Gestational Diabetes
Mellitus: A Systematic Review and Meta-Analysis |
title_sort | association of blood lipocalin-2 levels with gestational diabetes
mellitus: a systematic review and meta-analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546583/ https://www.ncbi.nlm.nih.gov/pubmed/36206761 http://dx.doi.org/10.1055/a-1909-1922 |
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